Technology Process of ethyl (2R,3S)-4-phenyl-2,3-oxiranebutanoate
There total 3 articles about ethyl (2R,3S)-4-phenyl-2,3-oxiranebutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-benzyl-N-phenyloxirane-2-carboxamide;
With
dmap; di-tert-butyl dicarbonate;
In
dichloromethane; acetonitrile;
at 20 ℃;
sodium ethanolate;
In
ethanol;
at 0 ℃;
for 0.166667h;
optical yield given as %ee;
DOI:10.1002/anie.200903061
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 92 percent / sulfuryl chloride / CHCl3 / 20 °C
2: 82 percent / Escherichia coli BL21(DE3)(pIK4) overexpressing reductase; glucose; air / KPi buffer; XAD-4 resin / 24 h / 30 °C / pH 5.6
3: 99 percent / potassium carbonate / H2O; dimethylformamide / 5 h / 20 °C
With
sulfuryl dichloride; air; D-glucose; Escherichia coli BL21(DE3)(pIK4) overexpressing reductase; potassium carbonate;
KPi buffer; XAD-4 resin;
In
chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2005.08.022
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 82 percent / Escherichia coli BL21(DE3)(pIK4) overexpressing reductase; glucose; air / KPi buffer; XAD-4 resin / 24 h / 30 °C / pH 5.6
2: 99 percent / potassium carbonate / H2O; dimethylformamide / 5 h / 20 °C
With
air; D-glucose; Escherichia coli BL21(DE3)(pIK4) overexpressing reductase; potassium carbonate;
KPi buffer; XAD-4 resin;
In
water; N,N-dimethyl-formamide;
DOI:10.1016/j.tetasy.2005.08.022
