2,2-dimethyl-N-(2-(3-fluoro-2-(2'-pyridyl)-4-pyridyl)phenyl)propanamide

Base Information

Chemical Name:2,2-dimethyl-N-(2-(3-fluoro-2-(2'-pyridyl)-4-pyridyl)phenyl)propanamide
CAS No.:148639-11-6
Molecular Formula:C₂₁H₂₀FN₃O
Molecular Weight:349.408
Hs Code.:

Synonyms:2,2-dimethyl-N-(2-(3-fluoro-2-(2'-pyridyl)-4-pyridyl)phenyl)propanamide

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Chemical Property of 2,2-dimethyl-N-(2-(3-fluoro-2-(2'-pyridyl)-4-pyridyl)phenyl)propanamide

Chemical Property:

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Technology Process of 2,2-dimethyl-N-(2-(3-fluoro-2-(2'-pyridyl)-4-pyridyl)phenyl)propanamide

There total 3 articles about 2,2-dimethyl-N-(2-(3-fluoro-2-(2'-pyridyl)-4-pyridyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 13737-05-8
2-trimethylstannylpyridine

: 148639-08-1
2,2-dimethyl-N-(2-(2-chloro-3-fluoro-4-pyridyl)phenyl)propanamide

: 148639-11-6
2,2-dimethyl-N-(2-(3-fluoro-2-(2'-pyridyl)-4-pyridyl)phenyl)propanamide

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 60h; Heating;
DOI:10.1016/S0040-4020(01)90161-9

Reference yield:

: 6298-19-7
2-chloro-3-aminopyridine

: 148639-11-6
2,2-dimethyl-N-(2-(3-fluoro-2-(2'-pyridyl)-4-pyridyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / EtNO₂, 34percent HBF₄

2: 1) (i-Pr)2NLi, 2) I₂ / 1) THF, hexane, -75 deg C, 4 h, 2) THF, -75 deg C, 1 h

3: 1) K₂CO₃ / 2) Pd(PPh₃)4 / 1) EtOH, toluene, 0.5 h, 2) reflux, 48 h

4: 92 percent / Pd(PPh₃)4 / toluene / 60 h / Heating

With tetrafluoroboric acid; Nitroethane; iodine; potassium carbonate; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene;
DOI:10.1016/S0040-4020(01)90161-9

Reference yield:

: 148639-07-0
2-chloro-3-fluoro-4-iodopyridyne

: 148639-11-6
2,2-dimethyl-N-(2-(3-fluoro-2-(2'-pyridyl)-4-pyridyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1) K₂CO₃ / 2) Pd(PPh₃)4 / 1) EtOH, toluene, 0.5 h, 2) reflux, 48 h

2: 92 percent / Pd(PPh₃)4 / toluene / 60 h / Heating

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene;
DOI:10.1016/S0040-4020(01)90161-9