trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylic acid trifluoroacetate

Base Information

• Chemical Name: trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylic acid trifluoroacetate
• CAS No.: 1010086-87-9
• Molecular Formula: C₂HF₃O₂*C₂₇H₃₀F₄N₄O₃
• Molecular Weight: 648.578

Synonyms:trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylic acid trifluoroacetate

Chemical Property of trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylic acid trifluoroacetate

Chemical Property:

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Safty Information:

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Technology Process of trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylic acid trifluoroacetate

There total 1 articles about trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylic acid trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylate (1010086-59-5) + trifluoroacetic acid (76-05-1) → trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylic acid trifluoroacetate (1010086-87-9)

Guidance literature:

In chloroform; at 0 - 20 ℃;

Reference yield:

trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylic acid trifluoroacetate (1010086-87-9) + formic acid hydrazide (624-84-0) → trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)-N'-formylcyclohexanecarbohydrazide (1010087-03-2)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃;

Reference yield:

trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylic acid trifluoroacetate (1010086-87-9) + t-butoxycarbonylhydrazine (870-46-2) → tert-butyl 2-((trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexyl)carbonyl)hydrazinecarboxylate (1010086-89-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 8h;

upstream raw materials:

tert-butyl trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexanecarboxylate

trifluoroacetic acid

Downstream raw materials:

tert-butyl 2-((trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)cyclohexyl)carbonyl)hydrazinecarboxylate

trans-1-((6-((1-tert-butyl-1H-pyrazol-5-yl)amino)pyridin-2-yl)methyl)-4-(2-fluoro-3-(trifluoromethyl)phenoxy)-N'-formylcyclohexanecarbohydrazide

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