methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate

Base Information

Chemical Name:methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate
CAS No.:1239960-11-2
Molecular Formula:C₂₇H₂₁Cl₃F₂N₂O₃
Molecular Weight:565.831
Hs Code.:

Synonyms:methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate

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Chemical Property of methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate

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Technology Process of methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate

There total 13 articles about methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1239963-66-6
2-(chloromethyl)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 455-57-2
3-chloro-5-fluoro-4-hydroxy-benzoic acid

: 1239960-11-2
methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate

Guidance literature:: With potassium carbonate; 18-crown-6 ether; In acetonitrile; at 60 ℃; for 8h;

Reference yield: 68.0%

: 1239963-66-6
2-(chloromethyl)-5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 369-15-3
3-chloro-5-fluoro-4-hydroxy-benzoic acid methyl ester

: 1239960-11-2
methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate

Guidance literature:: With 18-crown-6 ether; potassium carbonate; In acetonitrile; at 60 ℃; for 8h;

Reference yield:

: 2-(3,4-dichlorophenyl)-2-methylpropanenitrile

: 1239960-11-2
methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate

Guidance literature:: Multi-step reaction with 11 steps

1.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: diethyl ether / 3 h / 0 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

3.2: 1 h / -78 - 20 °C

4.1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 24 h

5.1: hexamethylenetetramine / dichloromethane / 48 h / 20 °C

5.2: 2 h / Reflux

6.1: triethylamine / benzene / 6 h / Reflux

7.1: dihydrogen peroxide; acetic acid / dichloromethane / 6.67 h / 0 - 20 °C

8.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

8.2: 3 h / -78 °C

9.1: sodium tetrahydroborate / ethanol / 3 h

10.1: thionyl chloride / acetonitrile / 3 h / 0 °C

11.1: potassium carbonate; 18-crown-6 ether / acetonitrile / 8 h / 60 °C

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; tetra-n-butylammonium tribromide; oxalyl dichloride; 18-crown-6 ether; hexamethylenetetramine; dihydrogen peroxide; diisobutylaluminium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; toluene; acetonitrile; benzene;