3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoic acid

Base Information

Chemical Name:3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoic acid
CAS No.:1239957-25-5
Molecular Formula:C₂₆H₁₉Cl₃F₂N₂O₃
Molecular Weight:551.804
Hs Code.:

Synonyms:3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoic acid

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Chemical Property of 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoic acid

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Technology Process of 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoic acid

There total 13 articles about 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1239960-11-2
methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate

: 1239957-25-5
3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoic acid

Guidance literature:: methyl 3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoate; With sodium hydroxide; In methanol; at 65 ℃; for 3h;

With hydrogenchloride; In methanol; water; pH=3;

Reference yield:

: 1239963-63-3
5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole

: 1239957-25-5
3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

1.2: 3 h / -78 °C

2.1: sodium tetrahydroborate / ethanol / 3 h

3.1: thionyl chloride / acetonitrile / 3 h / 0 °C

4.1: potassium carbonate; 18-crown-6 ether / acetonitrile / 8 h / 60 °C

5.1: sodium hydroxide / methanol / 3 h / 65 °C

5.2: pH 3

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; 18-crown-6 ether; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; acetonitrile;

Reference yield:

: 2-(3,4-dichlorophenyl)-2-methylpropanenitrile

: 1239957-25-5
3-chloro-4-((5-(2-(3,4-dichlorophenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-yl)methoxy)-5-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 12 steps

1.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

1.2: 1 h / -78 - 20 °C

2.1: diethyl ether / 3 h / 0 - 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / -78 °C

3.2: 1 h / -78 - 20 °C

4.1: tetra-n-butylammonium tribromide / dichloromethane; methanol / 24 h

5.1: hexamethylenetetramine / dichloromethane / 48 h / 20 °C

5.2: 2 h / Reflux

6.1: triethylamine / benzene / 6 h / Reflux

7.1: dihydrogen peroxide; acetic acid / dichloromethane / 6.67 h / 0 - 20 °C

8.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C

8.2: 3 h / -78 °C

9.1: sodium tetrahydroborate / ethanol / 3 h

10.1: thionyl chloride / acetonitrile / 3 h / 0 °C

11.1: potassium carbonate; 18-crown-6 ether / acetonitrile / 8 h / 60 °C

12.1: sodium hydroxide / methanol / 3 h / 65 °C

12.2: pH 3

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; tetra-n-butylammonium tribromide; oxalyl dichloride; 18-crown-6 ether; hexamethylenetetramine; dihydrogen peroxide; diisobutylaluminium hydride; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; hexane; dichloromethane; toluene; acetonitrile; benzene;