3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid

Base Information

• Chemical Name: 3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid
• CAS No.: 1148627-92-2
• Molecular Formula: C₃₈H₄₄N₆O₁₀S₄
• Molecular Weight: 873.066
• Mol file: 1148627-92-2.mol

Synonyms:3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid

Chemical Property of 3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid

There total 4 articles about 3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid dimethyl ester (1148627-89-7) → 3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid (1148627-92-2)

Guidance literature:

With water; potassium hydroxide; In 1,4-dioxane; at 60 ℃; for 6h;

DOI:10.1016/j.tet.2011.01.008

Reference yield:

tert-butyl N-(2-aminoethyl)-N-[2-(2-aminoethyl(tert-butoxycarbonyl)amino)ethyl]carbamate (206531-21-7) → 3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid (1148627-92-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 16 h / 0 - 25 °C / Inert atmosphere

3: Lawessons reagent / toluene / 3 h / Reflux

4: water; potassium hydroxide / 1,4-dioxane / 6 h / 60 °C

With Lawessons reagent; Bromotrichloromethane; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In 1,4-dioxane; dichloromethane; toluene;

DOI:10.1016/j.tet.2011.01.008

Reference yield:

C40H52N6O12S2 (1148627-83-1) → 3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid (1148627-92-2)

Guidance literature:

Multi-step reaction with 3 steps

1: Bromotrichloromethane; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 16 h / 0 - 25 °C / Inert atmosphere

2: Lawessons reagent / toluene / 3 h / Reflux

3: water; potassium hydroxide / 1,4-dioxane / 6 h / 60 °C

With Lawessons reagent; Bromotrichloromethane; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; potassium hydroxide; In 1,4-dioxane; dichloromethane; toluene;

DOI:10.1016/j.tet.2011.01.008

upstream raw materials:

C₄₀H₅₂N₆O₁₂S₂

3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid dimethyl ester

3,3'-[1,2-ethanediylbis[[[(1,1-dimethylethoxy)carbonyl]imino]-2,1-ethanediyliminocarbonothioyl-4,2-thiazolediyl]]-bis[4-hydroxy]benzoic acid dimethyl ester

tert-butyl N-(2-aminoethyl)-N-[2-(2-aminoethyl(tert-butoxycarbonyl)amino)ethyl]carbamate