4,6-Diethoxy-2-(p-formylphenyl)-pyrimidine

Base Information

Chemical Name:4,6-Diethoxy-2-(p-formylphenyl)-pyrimidine
CAS No.:77232-40-7
Molecular Formula:C₁₅H₁₆N₂O₃
Molecular Weight:272.304
Hs Code.:
DSSTox Substance ID:DTXSID101267074

Synonyms:4,6-diethoxy-2-(p-formylphenyl)-pyrimidine;SCHEMBL11200168;GHUZIXIVUORBKW-UHFFFAOYSA-N;DTXSID101267074;77232-40-7;4-(4,6-Diethoxy-2-pyrimidinyl)benzaldehyde

Suppliers and Price of 4,6-Diethoxy-2-(p-formylphenyl)-pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,6-Diethoxy-2-(p-formylphenyl)-pyrimidine

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:272.11609238
Heavy Atom Count:20
Complexity:279

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC1=CC(=NC(=N1)C2=CC=C(C=C2)C=O)OCC

Technology Process of 4,6-Diethoxy-2-(p-formylphenyl)-pyrimidine

There total 6 articles about 4,6-Diethoxy-2-(p-formylphenyl)-pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.6%

: 77232-39-4
2-(4-Bromomethyl-phenyl)-4,6-diethoxy-pyrimidine

: 77232-40-7
4,6-Diethoxy-2-(4-formylphenyl)-pyrimidine

Guidance literature:: With ethanol; 2-nitropropane; sodium; In N,N-dimethyl-formamide; at 60 - 65 ℃; for 2h;
DOI:10.1002/hlca.19810640114

Reference yield:

: 6326-27-8
p-methylbenzamidine hydrochloride

: 77232-40-7
4,6-Diethoxy-2-(4-formylphenyl)-pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: 89.6 percent / sodium methylate / ethanol; methanol / 5 h / Heating

2: 89.2 percent / phosphorus oxychloride, N,N-dimethylaniline / 1 h / Heating

3: 92.3 percent / 5 h / Heating

4: 61.8 percent / N-bromosuccinimide, dibenzoylperoxide, α,α'-azoisobutyronitrile / CCl4 / 3 h / Heating; Irradiation

5: 58.6 percent / sodium, ethanol, 2-nitropropane / dimethylformamide / 2 h / 60 - 65 °C

With N-Bromosuccinimide; ethanol; 2-nitropropane; azobisisobutyronitrile; sodium methylate; sodium; N,N-dimethyl-aniline; trichlorophosphate; dibenzoyl peroxide; In methanol; tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19810640114

Reference yield:

: 21139-61-7
2-(4-methylphenyl)-4,6-dichloropyrimidine

: 77232-40-7
4,6-Diethoxy-2-(4-formylphenyl)-pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 92.3 percent / 5 h / Heating

2: 61.8 percent / N-bromosuccinimide, dibenzoylperoxide, α,α'-azoisobutyronitrile / CCl4 / 3 h / Heating; Irradiation

3: 58.6 percent / sodium, ethanol, 2-nitropropane / dimethylformamide / 2 h / 60 - 65 °C

With N-Bromosuccinimide; ethanol; 2-nitropropane; azobisisobutyronitrile; sodium; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19810640114