6326-27-8

Usage

Uses

4-Methylbenzimidamide, HCl

InChI:InChI=1/C8H10N2/c1-6-2-4-7(5-3-6)8(9)10/h2-5H,1H3,(H3,9,10)/p+1

Upstream product

• 39739-50-9 p-toluimidic acid methyl ester hydrochloride 
• 43002-64-8 ethyl 4-methylbenzimidate hydrochloride 
• 19227-13-5 p-toluamidoxime 
• 72525-60-1 hexamethyldisilazan 
• 104-85-8 para-methylbenzonitrile 

Downstream Products

• 30886-10-3 4,6-bis(4-methylphenyl)-2-oxo-2,3-dihydro-sym-triazine 
• 14727-23-2 6-methyl-2-(4-methylphenyl)pyrimidin-4-one 
• 77232-20-3 6-phenyl-2-p-tolyl-3H-pyrimidin-4-one 
• 79957-47-4 4-p-Methoxybenzylidene-2-p-tolyl-2-imidazolin-5-one 
• 77232-12-3 2-(4-methylphenyl)-4,6-dihydroxypyrimidine 
• 79382-77-7 4-chloro-6-methyl-2-(4-methylphenyl)pyrimidine 
• 477879-73-5 N-{1-[3-(4-Methylphenyl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl]propyl}acetamide 
• 1013658-87-1 C₂₁H₂₀N₂O₂ 
• 1062512-48-4 1-(3-p-tolyl-[1,2,4]thiadiazol-5-yl)-piperazine 
• 32622-41-6 6-p-tolyl-4-thioxo-3,4-dihydro-1,3,5-triazin-2(1H)-one 
• 18818-41-2 2-(4-methylphenyl)-4(3H)-quinazolinone 
• 1292783-82-4 4-(4-chlorophenyl)-2-(4-methylphenyl)pyrimidine 
• 1292783-85-7 2,4-bis(4-methylphenyl)pyrimidine 
• 1196082-32-2 5,6,7,8-tetrahydro-2-(4-methylphenyl)quinazoline 

Relevant academic research and scientific papers

Silver-catalyzed [3+2+1] annulation of aryl amidines with benzyl isocyanide

A silver-catalyzed [3+2+1] annulation of amidines with benzyl isocyanide toward 2,4-diaryl-1,3,5-triazines was developed. A variety of symmetrical and unsymmetrical products were obtained in moderate to good yields. This work also features an oxidant-free approach to 2,4-disubstituted triazines.

Transition-metal-free approach to 4-ethynylpyrimidines via alkenynones

A practical approach to the synthesis of 4-ethynylpyrimidines by the condensation of arylamidines with 2-aryl-1-ethoxy-5-(trimethylsilyl)pent-1-en-4- yn-3-ones has been developed. As these latter ketones are easily accessible from bis(trimethylsilyl)acetylene and arylacetyl chlorides, the regioselective condensation reported herein provides a facile access to both TMS-protected and unprotected 4-ethynylpyrimidines in yields of up to 85%. Copyright

Synthesis and structure of aroylamidines and N-arylbenzamidines hydrochlorides

Aroylamidines can be obtained as salts in a reaction of the corresponding arylcarbonitriles with anhydrous ethanol in the presence of dry HCl followed by treating intermediate imidoesters with alcoholic solution of ammonia. N-Arylbenzamidines are obtained by reacting benzonitrile with arylamines in the presence of AlCl3. The structure of arylamines and the reaction conditions signifi cantly affect the yield of the target product, and sometimes the very possibility of its preparation. Pleiades Publishing, Ltd., 2012.

Preparation of amidines from amidoximes via transfer hydrogenation

Amidoximes are reduced into amidine using triethyl silane and PdCl 2 in acetic acid. Copyright

Dimerization and trapping of diazirinyl radicals

Computational and experimental methods have been utilized to examine the facile dimerization of diazirinyl radicals. Two potential dimers were investigated using density functional theory. Both were shown to have low-barrier reaction coordinates leading t

Process for the production of nitrogen compounds

A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.

Diaryl substituted thiazoles useful in the treatment of fungal infections

Disclosed is a novel class of thiazole, thiadiazole, and oxadiazole compounds which are substituted at their nuclear carbons by aromatic moieties. These compounds exhibit antifungal activity against a variety of fungi including strains which have proven to be resistant to treatment with known antifungal agents such as Fluconazole.

AZIDE AND FLUORIDE EXCHANGE REACTIONS OF HALODIAZIRINES

Reactions of 3-aryl-3-bromodiazirines (11) with molten tetrabutylammonium fluoride at 25degC provide 65-74percent isolated vields of the novel corresponding 3-aryl-3-fluorodiazirines (12) Related reactions of 11 with tetrabutylammonium azide afford high yields of aryl nitriles.The latter reactions are believed to proceed through unstable intermediate 3-aryl-3-azidodiazirines (7).These reactions involve rate-determining formation of 7 and display kinetics which are first order in azide ion and bromodiazirine.The likely intermediacy of aryldiazirinium bromide ion pair between 11 and 7 is supported by a combination of salt effect, leaving group effect and Hammett studies.Molecular orbital calculations are employed to characterize azidodiazirines as well as the mode of their decomposition to nitriles.In particular, we consider the possible itermediacy of a 3-nitrenodiazirine or an azidocarbene.