N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-yl}urea

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Chemical Name:N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-yl}urea
CAS No.:1357621-27-2
Molecular Formula:C₂₆H₃₀N₆O₂S
Molecular Weight:490.629
Hs Code.:

Synonyms:N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-yl}urea

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Chemical Property of N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-yl}urea

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Technology Process of N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-yl}urea

There total 6 articles about N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-yl}urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 317806-87-4
2,2,2-trichloroethyl 3-tert-butyl-1-p-tolyl-1H-pyrazol-5-ylcarbamate

: C₁₁H₁₃N₃OS*ClH

: 1357621-27-2
N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-yl}urea

Guidance literature:: C₁₁H₁₃N₃OS*ClH; With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 20 ℃; for 0.166667h; Inert atmosphere;

2,2,2-trichloroethyl 3-tert-butyl-1-p-tolyl-1H-pyrazol-5-ylcarbamate; In dimethyl sulfoxide; at 60 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

: 147284-02-4
tert-butyl 4-(2-hydroxyethyl)-1,3-thiazol-2-ylcarbamate

: 1357621-27-2
N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-yl}urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 3 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 24 h

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere

4.2: 60 °C / Inert atmosphere

With pyridine; hydrogenchloride; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.11.019

Reference yield:

: 1357620-95-1
tert-butyl 4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-ylcarbamate

: 1357621-27-2
N-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-{4-[2-(3-pyridinylmethoxy)ethyl]-1,3-thiazol-2-yl}urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 24 h

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere

2.2: 60 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dimethyl sulfoxide;
DOI:10.1016/j.ejmech.2011.11.019