Technology Process of 2-(2,4-dichloro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
There total 3 articles about 2-(2,4-dichloro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,5-dichloro-2-iodo-3-methoxybenzene; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane;
With
sodium hydride;
copper(l) iodide;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 16h;
Inert atmosphere;
With
ammonium chloride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h
2.1: sodium hydride / copper(l) iodide / tetrahydrofuran; mineral oil / 16 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
With
sodium hydride; caesium carbonate;
copper(l) iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / toluene; mineral oil / 0.33 h / 0 - 20 °C
1.2: 16 h / 20 °C
1.3: 20 °C
2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h
3.1: sodium hydride / copper(l) iodide / tetrahydrofuran; mineral oil / 16 h / 20 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
With
sodium hydride; caesium carbonate;
copper(l) iodide;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene; mineral oil;
