7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

Base Information

Chemical Name:7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol
CAS No.:911837-41-7
Molecular Formula:C₄₆H₆₆O₆Si₂
Molecular Weight:771.197
Hs Code.:

7-benzyloxy-5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

Synonyms:7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

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Chemical Property of 7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

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Technology Process of 7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

There total 11 articles about 7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 911837-50-8
7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptanal

: 911837-41-7
7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol;
DOI:10.1016/j.tetlet.2006.06.173

Reference yield:

: 872369-16-9
(?)-(2S,3S)-5-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-2-methylpentan-1-ol

: 911837-41-7
7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / Bu₂BOTf; Et₃N

2: 93 percent / NaBH₄ / tetrahydrofuran; H₂O

3: 95 percent / CSA / CH₂Cl₂

4: 95 percent / DIBAL-H / CH₂Cl₂ / 0 °C

5: 95 percent / 4-DMAP; pyridine / CH₂Cl₂; dimethylformamide

6: 90 percent / OsO₄; NMO; NaIO₄ / 2-methyl-propan-2-ol; H₂O

7: 100 percent / NaBH₄ / methanol

With pyridine; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Swern oxidation / 2: Evans aldol condensation;
DOI:10.1016/j.tetlet.2006.06.173

Reference yield:

: 870091-89-7
(-)-(R)-4-benzyl-3-[(2R,3S)-5-(benzyloxy)-3-hydroxy-2-methylpentanoyl]-1,3-oxazolidin-2-one

: 911837-41-7
7-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-(4-methoxy-benzyloxy)-4-methyl-heptan-1-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 95 percent / imidazole / dimethylformamide

2: 90 percent / NaBH₄ / tetrahydrofuran; H₂O

3: 96 percent / Bu₂BOTf; Et₃N

4: 93 percent / NaBH₄ / tetrahydrofuran; H₂O

5: 95 percent / CSA / CH₂Cl₂

6: 95 percent / DIBAL-H / CH₂Cl₂ / 0 °C

7: 95 percent / 4-DMAP; pyridine / CH₂Cl₂; dimethylformamide

8: 90 percent / OsO₄; NMO; NaIO₄ / 2-methyl-propan-2-ol; H₂O

9: 100 percent / NaBH₄ / methanol

With pyridine; 1H-imidazole; dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; di-n-butylboryl trifluoromethanesulfonate; camphor-10-sulfonic acid; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol; 3: Swern oxidation / 4: Evans aldol condensation;
DOI:10.1016/j.tetlet.2006.06.173