methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate

Base Information

Chemical Name:methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate
CAS No.:142335-18-0
Molecular Formula:C₁₇H₂₃ClFN₃O₃S
Molecular Weight:403.905
Hs Code.:

Synonyms:methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate

Suppliers and Price of methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate

There total 8 articles about methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 75-04-7,85404-22-4
ethylamine

: 142335-17-9,142335-26-0
methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-dimethylaminoacrylate

: 142335-18-0
methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate

Guidance literature:: In tert-butyl alcohol; at 55 - 60 ℃; for 2.5h;
DOI:10.1002/jhet.5570290215

Reference yield:

: 109-01-3
1-methyl-piperazine

: 142335-18-0
methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / dimethylformamide / 1 h / 110 - 120 °C

2: 1.) sodium nitrite, conc. H₂SO₄, 2.) CuCl, conc. HCl / 1.) glacial AcOH, 40deg C, 30 min, 2.) 80 frg c

3: 91 percent / SnCl₂*H₂O, conc. HCl / 1 h / Heating

4: 1.) NaNO₂, conc. HCl, 2.) potassium-ethylxantate, 3.) KOH

5: 60 percent / 35percent H₂O₂ / acetic acid / 48 h / Ambient temperature

6: 66 percent / tetrahydrofuran / 2 h / 80 °C

7: 89 percent / 2-methyl-propan-2-ol / 2.5 h / 55 - 60 °C

With hydrogenchloride; potassium hydroxide; potassium-ethylxantate; sulfuric acid; dihydrogen peroxide; copper(l) chloride; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/jhet.5570290215

Reference yield:

: 81962-58-5
N-(3-chloro-4-fluoro-2-nitrophenyl)acetamide

: 142335-18-0
methyl 2-<2-chloro-5-fluoro-4-(4-methyl-1-piperazinyl)phenylsulfinyl>-3-ethylaminoacrylate

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / dimethylformamide / 1 h / 110 - 120 °C

2: 1.) sodium nitrite, conc. H₂SO₄, 2.) CuCl, conc. HCl / 1.) glacial AcOH, 40deg C, 30 min, 2.) 80 frg c

3: 91 percent / SnCl₂*H₂O, conc. HCl / 1 h / Heating

4: 1.) NaNO₂, conc. HCl, 2.) potassium-ethylxantate, 3.) KOH

5: 60 percent / 35percent H₂O₂ / acetic acid / 48 h / Ambient temperature

6: 66 percent / tetrahydrofuran / 2 h / 80 °C

7: 89 percent / 2-methyl-propan-2-ol / 2.5 h / 55 - 60 °C

With hydrogenchloride; potassium hydroxide; potassium-ethylxantate; sulfuric acid; dihydrogen peroxide; copper(l) chloride; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1002/jhet.5570290215