4-N-Maleimidobenzoic acid-NHS

Base Information

• Chemical Name: 4-N-Maleimidobenzoic acid-NHS
• CAS No.: 64191-06-6
• Molecular Formula: C15H10 N2 O6
• Molecular Weight: 314.254
• Hs Code.: 2925190090
• Mol file: 64191-06-6.mol

Synonyms:1H-Pyrrole-2,5-dione,1-[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]phenyl]- (9CI);p-Maleimidobenzoic acid N-hydroxysuccinimide ester

Chemical Property of 4-N-Maleimidobenzoic acid-NHS

Chemical Property:

• Melting Point: 205-207 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
• Boiling Point: 523.0±52.0 °C(Predicted)
• PKA: -4.69±0.20(Predicted)
• PSA: 101.06000
• Density: 1.59±0.1 g/cm3(Predicted)
• LogP: 0.33970

Purity/Quality:

97% ^*data from raw suppliers

4-N-MALEIMIDOBENZOIC ACID-NHS 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-N-Maleimidobenzoic acid-NHS

There total 9 articles about 4-N-Maleimidobenzoic acid-NHS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-(4-carboxyphenyl)maleimide (17057-04-4) → 2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate (64191-06-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; 1.) -15 deg C, 2 h; 2.) r. t., 3 h;

Reference yield: 83.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + N-(4-carboxyphenyl)maleamic acid (5432-04-2) → 2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate (64191-06-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide; 1.) -15 deg C, 2 h; 2.) r. t., 3 h;

Reference yield: 80.0%

N-trifluoroacetoxy succinimide (5672-89-9) + N-(4-carboxyphenyl)maleamic acid (5432-04-2) → 2,5-dioxopyrrolidin-1-yl 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate (64191-06-6)

Guidance literature:

With 2,4,6-trimethyl-pyridine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1080/00397910701750151

upstream raw materials:

maleic anhydride

1-hydroxy-pyrrolidine-2,5-dione

4-amino-benzoic acid

N-(4-carboxyphenyl)maleimide

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