N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide;

Base Information

Chemical Name:N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide;
CAS No.:1235871-32-5
Molecular Formula:C₃₃H₂₆BrNO₅
Molecular Weight:596.477
Hs Code.:

Synonyms:N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide;

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide;

There total 7 articles about N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide; which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1235871-31-4
N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromobenzo[d][1,3]dioxole-4-carboxamide

: 74-88-4
methyl iodide

: 1235871-32-5
N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide;

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2012.09.097

Reference yield:

: 1235871-28-9
1-bromo-5-nitro-2,3-dimethoxynaphthalene

: 1235871-32-5
N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide;

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; toluene / 90 °C

2: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 85 °C

3: triethylamine / dichloromethane / 20 °C

4: sodium hydride / N,N-dimethyl-formamide / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; sodium hydride; sodium carbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2012.09.097

Reference yield:

: 1235871-29-0
1-(biphenyl[1,1']-4-yl)-2,3-dimethoxy-5-nitronaphthalene

: 1235871-32-5
N-(5-([1,1'-biphenyl]-4-yl)-6,7-dimethoxynaphthalen-1-yl)-5-bromo-N-methylbenzo[1,3]dioxole-4-carboxamide;

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrazine hydrate / ethanol / 85 °C

2: triethylamine / dichloromethane / 20 °C

3: sodium hydride / N,N-dimethyl-formamide / 20 °C

With palladium 10% on activated carbon; sodium hydride; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.09.097