Technology Process of (S)-2-(3,5-dimethylbenzyl)piperidine
There total 6 articles about (S)-2-(3,5-dimethylbenzyl)piperidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3,5-dimethylbenzyl)piperidine;
With
Chiralpak AD preparative HPLC column;
In
carbon dioxide; isopropylamine; isopropyl alcohol;
optical yield given as %ee;
Resolution of racemate;
DOI:10.1016/j.bmcl.2012.02.049
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sulfuric acid; hydrogen / palladium 10% on activated carbon / methanol; water / 6 h / 50 °C / 3087.28 Torr
2: carbon dioxide; isopropylamine / isopropyl alcohol / Resolution of racemate
With
carbon dioxide; sulfuric acid; hydrogen; isopropylamine;
palladium 10% on activated carbon;
In
methanol; water; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: iodine; magnesium / tetrahydrofuran / 0 °C / Reflux
1.2: 0 - 20 °C
2.1: sulfuric acid; hydrogen / palladium 10% on activated carbon / methanol; water / 6 h / 50 °C / 3087.28 Torr
3.1: carbon dioxide; isopropylamine / isopropyl alcohol / Resolution of racemate
With
carbon dioxide; sulfuric acid; hydrogen; iodine; magnesium; isopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; water; isopropyl alcohol;
1.1: Grignard Reaction;
