4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide

Base Information

• Chemical Name: 4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide
• CAS No.: 453523-36-9
• Molecular Formula: C₁₄H₁₅N₃O₂S
• Molecular Weight: 289.358
• Mol file: 453523-36-9.mol

Synonyms:4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide

Chemical Property of 4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide

There total 1 articles about 4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl-3-pyridylketone (350-03-8) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide (453523-36-9)

Guidance literature:

In methanol; at 60 ℃;

DOI:10.1021/acs.joc.9b02018

Reference yield: 93.0%

2,2,2-Trifluoroacetophenone (434-45-7) + 4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide (453523-36-9) → C15H12F3NO

Guidance literature:

4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide; With N-benzyl-N,N,N-triethylammonium chloride; caesium carbonate; In toluene; at 25 ℃; for 1h;

2,2,2-Trifluoroacetophenone; In toluene; at 90 ℃; for 12h; diastereoselective reaction;

Reference yield: 93.0%

2,2,2-Trifluoroacetophenone (434-45-7) + 4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide (453523-36-9) → 3-(trans-2-methyl-3-phenyl-3-(trifluoromethyl)oxiran-2-yl)pyridine

Guidance literature:

4-methyl-N′-(1-(pyridin-3-yl)ethylidene)benzenesulfonohydrazide; With caesium carbonate; In toluene; at 25 ℃; for 1h; Sealed tube;

2,2,2-Trifluoroacetophenone; With N-benzyl-N,N,N-triethylammonium chloride; In toluene; at 90 ℃; for 12h; diastereoselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.6b01824

upstream raw materials:

methyl-3-pyridylketone

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

3-ethylpyridine

3-(1-(4-chlorophenyl)vinyl)pyridine

4-(1-(pyridin-3-yl)vinyl)benzonitrile

C₁₅H₁₆N₂O