70857-49-7

Usage

InChI:InChI=1/C30H41N7O6/c1-19(2)25(27(40)34-22(18-38)16-20-10-5-3-6-11-20)37-26(39)23(14-9-15-33-29(31)32)35-30(43)36-24(28(41)42)17-21-12-7-4-8-13-21/h3-8,10-13,18-19,22-25H,9,14-17H2,1-2H3,(H,34,40)(H,37,39)(H,41,42)(H4,31,32,33)(H2,35,36,43)/t22-,23-,24-,25-/m0/s1

Upstream product

• 189563-95-9 C₄₁H₅₇N₇O₉S 
• 189563-89-1 C₃₄H₄₃N₅O₈S 
• 189563-90-4 C₂₇H₃₇N₅O₈S 
• 189563-82-4 L-phenylalanine t-butyl ester N-hydroxysuccinimide carboxamide 
• 16874-17-2 L-phenylalanine tert-butyl ester 
• 352229-64-2 C₄₁H₅₅N₇O₉S 
• 530-62-1 1,1'-carbonyldiimidazole 
• 212122-19-5 (S)-2-(3-{(S)-1-[(S)-1-((S)-1-Benzyl-2,3-dihydroxy-propylcarbamoyl)-2-methyl-propylcarbamoyl]-4-guanidino-butyl}-ureido)-3-phenyl-propionic acid 

Relevant academic research and scientific papers

First total synthesis of Mer-N5075A and a diastereomeric mixture of α and β-MAPI, new HIV-I protease inhibitors from a species of Streptomyces

Mer-N5075A (1) and α-MAPI and β-MAPI (2 and 3) produced from a species of Streptomyces are new anomalous tetrapeptides having potential HIV-I protease inhibitory activity. The first total synthesis of 1 and a diastereomeric mixture of 2 and 3 was achieved

First efficient synthesis of α-MAPI

α-MAPI 1 and its analogues have been synthesised using tri-tert-butoxysilyl protected amino acids in conjunction with a solid-phase N→C assembly; the terminal aldehyde group of the peptide is generated from a C-modified amino acid containing a gem-diol.