benzyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate
CAS No.:1401098-37-0
Molecular Formula:C₂₇H₃₃NO₅S
Molecular Weight:483.629
Hs Code.:

Synonyms:benzyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

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Chemical Property of benzyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

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Technology Process of benzyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

There total 5 articles about benzyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1401098-36-9
benzyl 4-((4-(trifluoromethylsulfonyloxy)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

: 149104-88-1
4-methanesulphonylphenylboronic acid

: 1401098-37-0
benzyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere; Sealed tube;

Reference yield:

: 159275-16-8
1-(benzyloxycarbonyl)piperidin-4-ylmethyl methanesulfonate

: 1401098-37-0
benzyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 1 h / 100 °C / Microwave irradiation

2.1: hydrogenchloride / tetrahydrofuran / 25 h / 20 - 40 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 1.5 h / -78 - 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; sodium hydride; sodium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 22428-87-1
4,4-ethylenedioxycyclohexan-1-ol

: 1401098-37-0
benzyl 4-((4-(4-(methylsulfonyl)phenyl)cyclohex-3-enyloxy)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 20 °C

1.2: 1 h / 100 °C / Microwave irradiation

2.1: hydrogenchloride / tetrahydrofuran / 25 h / 20 - 40 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

3.2: 1.5 h / -78 - 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; sodium hydride; sodium carbonate; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;