N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine

Base Information

Chemical Name:N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine
CAS No.:221665-11-8
Molecular Formula:C₃₁H₄₃N₅O₈S
Molecular Weight:645.777
Hs Code.:

Synonyms:N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine

Suppliers and Price of N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine

There total 1 articles about N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 2304-94-1
3-(benzyloxycarbonylamino)propanoic acid

: 112160-37-9
N^G-2,2,5,7,8-pentamethylchroman-6-sulfonyl-L-arginine

: 221665-11-8
N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine

Guidance literature:: With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm980728e

Reference yield: 78.0%

: 221665-11-8
N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine

: 74-88-4
methyl iodide

: 221665-13-0
N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine methyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; Ambient temperature;

Reference yield:

: 221665-11-8
N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine

: N-α-[[N-(benzyloxycarbonyl)aminocaproyl]-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / Cs₂CO₃ / dimethylformamide / 12 h / 20 °C

2: 99 percent / H₂ / 10 percent Pd/C / methanol / 3 h / 0 °C

3: 70 percent / 1-hydroxybenzotriazole; DCC / dimethylformamide / 18 h / 20 °C

With hydrogen; benzotriazol-1-ol; caesium carbonate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; 1: Esterification / 2: Hydrogenolysis / 3: Condensation;
DOI:10.1021/jm980728e