112160-37-9

Basic information

• Product Name: H-ARG(PMC)-OH
• Synonyms: ARGININE(PMC)-OH;H-ARG(PMC)-OH;N-OMEGA-(2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL)-L-ARGININE;NG-2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONYL-L-ARGININE;L-Arg(Pmc)-OH;Nw-(2,2,5,7,8-Pentamethylchroman-6-sulfonyl)-L-arginine≥ 99% (TLC)
• CAS NO: 112160-37-9
• Molecular Formula: C₂₀H₃₂N₄O₅S
• Molecular Weight: 440.56
• Mol File: 112160-37-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 648.932°C at 760 mmHg
• Flash Point: 346.262°C
• Appearance: /
• Density: 1.365g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Store at RT.
• PKA: 2.50±0.24(Predicted)
• CAS DataBase Reference: H-ARG(PMC)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: H-ARG(PMC)-OH(112160-37-9)
• EPA Substance Registry System: H-ARG(PMC)-OH(112160-37-9)

Safety Data

• Hazardous Substances Data: 112160-37-9(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C20H32N4O5S/c1-11-12(2)17(13(3)14-8-9-20(4,5)29-16(11)14)30(27,28)24-19(22)23-10-6-7-15(21)18(25)26/h15H,6-10,21H2,1-5H3,(H,25,26)(H3,22,23,24)/t15-/m0/s1

Upstream product

• 200125-12-8 N²-(tert-butoxycarbonyl)-N^ω-((2,2,5,7,8-pentamethylchroman-6-yl)sulfonyl)-L-arginine 
• 112160-32-4 C₂₈H₃₈N₄O₇S 
• 112160-39-1 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride 
• 697-82-5 2,3,5-trimethylphenol 
• 55646-01-0 2,2,5,7,8-pentamethyl-chromane 
• 112160-32-4 N_α-benzyloxycarbonyl-N_G-(2,2,5,7,8-pentamethylchroman-6-sulphonyl)-L-arginine 
• 78-79-5 isoprene 

Downstream Products

• 221665-11-8 N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine 
• 1182714-00-6 RGVGFIRF 
• 1239956-91-2 (S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid 
• 503173-71-5 L-aspartic acid, N-[(phenylmethoxy)carbonyl]glycyl-N⁵-({[(3,4-dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-yl)sulfonyl]amino}iminomethyl)-L-ornithylglycyl,-bis(1,1-dimethylethyl) ester 
• 221665-14-1 N-α-[N-(benzyloxycarbonyl)aminocaproyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine methyl ester 
• 221665-13-0 N-α-[N-(benzyloxycarbonyl)-β-alanyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine methyl ester 
• 221665-12-9 N-α-[N-(benzyloxycarbonyl)aminocaproyl]-N-(2,2,5,7,8-pentamethylchroman-6-sulfonyl)arginine 
• 74-79-3 L-arginine 

Relevant articles and documents

APPLICATION OF THE NG-(2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULPHONYL) DERIVATIVE OF FMOC-ARGININE TO PEPTIDE SYNTHESIS

The trifluoroacetic acid labile pentamethylchromanylsulphonyl protecting group for the guanidino group of arginine has been used in conjunction with the base-labile Fmoc Nα protecting group for the synthesis of arginine-containing peptides.

An acid labile arginine derivative for peptide synthesis: N(G)-2,2,5,7,8-pentamethylchroman-6-sulphonyl-L-arginine

A trifluoroacetic acid (TFA) labile protecting group for the guanidine side chain function of arginine has been developed. N(G)-(2,2,5,7,8-Pentamethylchroman-6-sulphonyl-L-arginine is cleaved rapidly in TFA or 50% TFA in dichloromethane at room temperatur

NG-2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULPHONYL-L-ARGININE: A NEW ACID LABILE DERIVATIVE FOR PEPTIDE SYNTHESIS

A new acid labile protecting group for the guanido side chain functionality of arginine has been developed.NG-(2,2,5,7,8-Pentamethylchroman-6-sulphonyl)-L-arginine, prepared from Nα-benzyloxycarbonyl-L-arginine and 2,2,5,7,8-pentamethylchroman-6-sulphonyl chloride, is cleaved rapidly in trifluoroacetic acid (TFA) or 50percent TFA in dichloromethane at room temperature.