methyl 6-(2-methoxyethoxy)-3-(2-methyl-3-nitrobenzoyl)-1H-indole-2-carboxylate

Base Information

Chemical Name:methyl 6-(2-methoxyethoxy)-3-(2-methyl-3-nitrobenzoyl)-1H-indole-2-carboxylate
CAS No.:1352836-44-2
Molecular Formula:C₂₁H₂₀N₂O₇
Molecular Weight:412.399
Hs Code.:

Synonyms:methyl 6-(2-methoxyethoxy)-3-(2-methyl-3-nitrobenzoyl)-1H-indole-2-carboxylate

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Chemical Property of methyl 6-(2-methoxyethoxy)-3-(2-methyl-3-nitrobenzoyl)-1H-indole-2-carboxylate

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Technology Process of methyl 6-(2-methoxyethoxy)-3-(2-methyl-3-nitrobenzoyl)-1H-indole-2-carboxylate

There total 1 articles about methyl 6-(2-methoxyethoxy)-3-(2-methyl-3-nitrobenzoyl)-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116350-38-0
6-hydroxy-1H-indole-2-carboxylic acid methyl ester

: 1352836-44-2
methyl 6-(2-methoxyethoxy)-3-(2-methyl-3-nitrobenzoyl)-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 55 °C / Inert atmosphere

2.1: tin(IV) chloride / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

2.2: 4.08 h

With tin(IV) chloride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1352836-44-2
methyl 6-(2-methoxyethoxy)-3-(2-methyl-3-nitrobenzoyl)-1H-indole-2-carboxylate

: 1352836-46-4
7-(2-methoxyethoxy)-1-(2-methyl-3-nitrophenyl)-3H-pyridazino[4,5-b]indol-4(5H)-one

Guidance literature:: With hydrazine hydrate; In ethanol; Inert atmosphere; Reflux;

Reference yield:

: 1352836-44-2
methyl 6-(2-methoxyethoxy)-3-(2-methyl-3-nitrobenzoyl)-1H-indole-2-carboxylate

: 1352836-60-2
1-(3-amino-2-methylphenyl)-7-(2-methoxyethoxy)-5H-pyridazino[4,5-b]indole-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / Inert atmosphere; Reflux

2.1: trichlorophosphate / 1 h / 100 °C / Inert atmosphere

2.2: Cooling with ice

3.1: sodium acetate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / N,N-dimethyl acetamide / 90 °C / 3620.13 Torr / Inert atmosphere

4.1: ammonia / methanol / 6.5 h / 100 °C / Sealed tube

With ammonia; sodium acetate; hydrazine hydrate; trichlorophosphate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In methanol; ethanol; N,N-dimethyl acetamide;