Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

Base Information

Chemical Name:Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn
CAS No.:1352134-26-9
Molecular Formula:C₂₉H₄₁F₆N₃O₆
Molecular Weight:641.651
Hs Code.:

Synonyms:Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

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Chemical Property of Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

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Technology Process of Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

There total 18 articles about Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: C₂HF₃O₂*C₁₈H₂₄F₄N₂O₃

: (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-4-methylpentanoic acid

: 1352134-26-9
Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

Guidance literature:: With 4-methyl-morpholine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;
DOI:10.1002/hlca.201100340

Reference yield:

: 1352133-79-9
C₂HF₃O₂*C₁₄H₁₉F₂NO₂

: 1352134-26-9
Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

2: dichloromethane / 1.5 h / 0 °C

3: 4-methyl-morpholine; HATU / dichloromethane; N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With 4-methyl-morpholine; HATU; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340

Reference yield:

: 1352134-25-8
Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

: 1352134-26-9
Boc-(3S)-β(2,2,3)-hVal(α,α-F2)-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 1.5 h / 0 °C

2: 4-methyl-morpholine; HATU / dichloromethane; N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With 4-methyl-morpholine; HATU; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340