Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

Base Information

Chemical Name:Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn
CAS No.:1352134-25-8
Molecular Formula:C₂₃H₃₂F₄N₂O₅
Molecular Weight:492.511
Hs Code.:

Synonyms:Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

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Chemical Property of Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

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Technology Process of Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

There total 10 articles about Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1352133-79-9
C₂HF₃O₂*C₁₄H₁₉F₂NO₂

: 3-tert-butoxycarbonylamino-2,2-difluoro-butyric acid

: 1352134-25-8
Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;
DOI:10.1002/hlca.201100340

Reference yield:

: 1352133-74-4
methyl (3S)-3-(tert-butoxycarbonylamino)-2,2-difluoro-5-methylhexanoate

: 1352134-25-8
Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hydroxide / ethanol; water / 1 h / 20 °C

1.2: 0 °C / Cooling with ice

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 12 h / 20 °C

3.1: dichloromethane / 1.5 h / 0 °C

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With 4-methyl-morpholine; caesium carbonate; HATU; lithium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340

Reference yield:

: 111060-65-2
(S)-2-(dibenzylamino)-4-methylpentanal

: 1352134-25-8
Boc-(3S)-β(2,2,3)-hAla(α,α-F2)-(3S)-β(2,2,3)-hLeu(α,α-F2)-OBn

Guidance literature:: Multi-step reaction with 9 steps

1.1: hexane; water / 0.08 h / 20 °C

1.2: 2 h / 20 °C

2.1: hydrogenchloride / 12 h / 20 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 - 20 °C / Inert atmosphere

4.1: diethylamino-sulfur trifluoride / dichloromethane / 6 h / 20 °C / Inert atmosphere

5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

6.1: lithium hydroxide / ethanol; water / 1 h / 20 °C

6.2: 0 °C / Cooling with ice

7.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

7.2: 12 h / 20 °C

8.1: dichloromethane / 1.5 h / 0 °C

9.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 12 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; oxalyl dichloride; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; caesium carbonate; dimethyl sulfoxide; HATU; lithium hydroxide; In methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340