3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

Base Information

Chemical Name:3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide
CAS No.:868286-37-7
Molecular Formula:C₁₈H₂₁FN₄O₄S
Molecular Weight:408.454
Hs Code.:

Synonyms:3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

Suppliers and Price of 3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

There total 10 articles about 3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868286-36-6
3-cyano-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

: 868286-37-7
3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

Guidance literature:: With hydroxylamine hydrochloride; water; potassium carbonate; isopropyl alcohol; at 130 ℃; for 0.0833333h; Microwave;

Reference yield:

: 695216-00-3
3-[(methylsulfonyl)amino]-5-nitrobenzoic acid methyl ester

: 868286-37-7
3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C

2.1: methanol; sodium hydroxide / tetrahydrofuran / 1.5 h / 20 °C

2.2: 20 °C / pH < 1

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 65 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

5.1: tetrafluoroboric acid / water; acetonitrile / 0.67 h / 0 - 20 °C

5.2: 1 h / 0 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide) / 0.5 h / 180 °C / Microwave

7.1: hydroxylamine hydrochloride; water; potassium carbonate; isopropyl alcohol / 0.08 h / 130 °C / Microwave

With methanol; sodium hydroxide; tetrafluoroboric acid; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropyl alcohol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 695216-01-4
3-[methyl(methylsulfonyl)amino]-5-nitrobenzoic acid methyl ester

: 868286-37-7
3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; sodium hydroxide / tetrahydrofuran / 1.5 h / 20 °C

1.2: 20 °C / pH < 1

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 65 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

4.1: tetrafluoroboric acid / water; acetonitrile / 0.67 h / 0 - 20 °C

4.2: 1 h / 0 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide) / 0.5 h / 180 °C / Microwave

6.1: hydroxylamine hydrochloride; water; potassium carbonate; isopropyl alcohol / 0.08 h / 130 °C / Microwave

With methanol; sodium hydroxide; tetrafluoroboric acid; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropyl alcohol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; acetonitrile;