ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate

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Chemical Name:ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate
CAS No.:1048666-17-6
Molecular Formula:C₂₀H₂₄FN₃O₄S
Molecular Weight:421.493
Hs Code.:

Synonyms:ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate

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Chemical Property of ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate

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Technology Process of ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate

There total 11 articles about ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868286-37-7
3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide

: 64-17-5
ethanol

: 1048666-17-6
ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate

Guidance literature:: 3-[amino(hydroxyimino)methyl]-N-[(1R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]benzamide; ethanol; With hydrogenchloride; In dichloromethane; at 0 - 20 ℃; for 20.5333h;

With ammonia; In diethyl ether; at 0 ℃; for 0.0166667h;

Reference yield:

: 695216-00-3
3-[(methylsulfonyl)amino]-5-nitrobenzoic acid methyl ester

: 1048666-17-6
ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 3 h / 20 °C

2.1: methanol; sodium hydroxide / tetrahydrofuran / 1.5 h / 20 °C

2.2: 20 °C / pH < 1

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 65 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

5.1: tetrafluoroboric acid / water; acetonitrile / 0.67 h / 0 - 20 °C

5.2: 1 h / 0 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide) / 0.5 h / 180 °C / Microwave

7.1: hydroxylamine hydrochloride; water; potassium carbonate; isopropyl alcohol / 0.08 h / 130 °C / Microwave

8.1: hydrogenchloride / dichloromethane / 20.53 h / 0 - 20 °C

8.2: 0.02 h / 0 °C

With hydrogenchloride; methanol; sodium hydroxide; tetrafluoroboric acid; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropyl alcohol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 695216-01-4
3-[methyl(methylsulfonyl)amino]-5-nitrobenzoic acid methyl ester

: 1048666-17-6
ethyl-3-({[(1R)-1-(4-fluorophenyl)ethyl]amino}carbonyl)-5-[methyl(methylsulfonyl)amino]benzenecarboximidoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: methanol; sodium hydroxide / tetrahydrofuran / 1.5 h / 20 °C

1.2: 20 °C / pH < 1

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 65 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h

4.1: tetrafluoroboric acid / water; acetonitrile / 0.67 h / 0 - 20 °C

4.2: 1 h / 0 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / DMF (N,N-dimethyl-formamide) / 0.5 h / 180 °C / Microwave

6.1: hydroxylamine hydrochloride; water; potassium carbonate; isopropyl alcohol / 0.08 h / 130 °C / Microwave

7.1: hydrogenchloride / dichloromethane / 20.53 h / 0 - 20 °C

7.2: 0.02 h / 0 °C

With hydrogenchloride; methanol; sodium hydroxide; tetrafluoroboric acid; 1-hydroxy-7-aza-benzotriazole; hydroxylamine hydrochloride; water; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; isopropyl alcohol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); ethanol; dichloromethane; water; acetonitrile;