N-((1H-indol-2-yl)methyl)-N-((7-chloroquinolin-2-yl)methyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-((1H-indol-2-yl)methyl)-N-((7-chloroquinolin-2-yl)methyl)-4-methylbenzenesulfonamide
CAS No.:1426678-86-5
Molecular Formula:C₂₆H₂₂ClN₃O₂S
Molecular Weight:475.999
Hs Code.:

Synonyms:N-((1H-indol-2-yl)methyl)-N-((7-chloroquinolin-2-yl)methyl)-4-methylbenzenesulfonamide

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Chemical Property of N-((1H-indol-2-yl)methyl)-N-((7-chloroquinolin-2-yl)methyl)-4-methylbenzenesulfonamide

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Technology Process of N-((1H-indol-2-yl)methyl)-N-((7-chloroquinolin-2-yl)methyl)-4-methylbenzenesulfonamide

There total 4 articles about N-((1H-indol-2-yl)methyl)-N-((7-chloroquinolin-2-yl)methyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21109-25-1
1-(1H-indol-2-yl)methanamine

: 1426678-86-5
N-((1H-indol-2-yl)methyl)-N-((7-chloroquinolin-2-yl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / 3.17 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane; 3.1: |Friedel-Crafts Alkylation;
DOI:10.1021/ol4002416

Reference yield:

: 1426679-01-7
C₂₀H₁₉N₃O

: 98-59-9
p-toluenesulfonyl chloride

: 1426678-86-5
N-((1H-indol-2-yl)methyl)-N-((7-chloroquinolin-2-yl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol4002416

Reference yield:

: 89060-22-0
6-methoxyquinoline-2-carboxaldehyde

: 1426678-86-5
N-((1H-indol-2-yl)methyl)-N-((7-chloroquinolin-2-yl)methyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanol / 20 °C / Inert atmosphere

2.1: sodium tetrahydroborate / 3.17 h / 0 - 20 °C / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; triethylamine; In methanol; dichloromethane; 3.1: |Friedel-Crafts Alkylation;
DOI:10.1021/ol4002416