6-METHOXY-QUINOLINE-2-CARBALDEHYDE

Base Information

• Chemical Name: 6-METHOXY-QUINOLINE-2-CARBALDEHYDE
• CAS No.: 89060-22-0
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Hs Code.: 2933499090
• Mol file: 89060-22-0.mol

Synonyms:6-methoxyquinoline-2-carboxaldehyde;6-Methoxy-2-chinolinaldehyd;6-methoxy-2-quinolinecarboxaldehyde;6-methoxy-2-quinolinecarbaldehyde;6-Methoxy-chinolin-2-carbaldehyd;6-METHOXY-QUINOLINE-2-CARBALDEHYDE;

Chemical Property of 6-METHOXY-QUINOLINE-2-CARBALDEHYDE

Chemical Property:

• Vapor Pressure: 3.52E-05mmHg at 25°C
• PSA: 39.19000
• LogP: 2.05590

Purity/Quality:

97% ^*data from raw suppliers

6-Methoxyquinoline-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-METHOXY-QUINOLINE-2-CARBALDEHYDE

There total 10 articles about 6-METHOXY-QUINOLINE-2-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

6-methoxyquinaldine (1078-28-0) → 6-methoxyquinoline-2-carboxaldehyde (89060-22-0)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dimethyl sulfoxide; at 120 ℃; for 0.5h; Solvent; regioselective reaction; Microwave irradiation; Sealed tube; Green chemistry;

DOI:10.1016/j.tetlet.2016.07.107

Reference yield: 60.0%

carbon monoxide (201230-82-2) + 2--bromo--6--methoxyquinoline (476161-59-8) → 6-methoxyquinoline-2-carboxaldehyde (89060-22-0)

Guidance literature:

With palladium diacetate; hydrogen; triphenylphosphine; 2,4,6-trimethyl-pyridine; tributyl-amine; In acetonitrile; at 120 ℃; for 18h; under 22501.8 Torr;

Reference yield: 21.0%

methanol (67-56-1) + 6-methoxy quinoline (5263-87-6) → 6-methoxyquinoline-2-carboxaldehyde (89060-22-0)

Guidance literature:

With tert.-butylhydroperoxide; iron(III)-acetylacetonate; acetic acid; at 110 ℃; for 9h; Sealed tube;

DOI:10.1039/d1ob01807h

upstream raw materials:

6-methoxyquinaldine

carbon monoxide

2--bromo--6--methoxyquinoline

6-hydroxyquinaldine

Downstream raw materials:

3-benzyl-8-methoxy-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline

N-({(4aS,R)-3-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinolin-8-yl}carbonyl)-4-({(1R)-3-(dimethylamino)-1-[(phenyl-sulphanyl)methyl]propyl}amino)-3-nitrobenzenesulphonamide

(4aS,R)-3-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylic acid hydrochloride

methyl (4aS,R)-3-[(4'-chloro-[1,1'-biphenyl]-2-yl)methyl]-2,3,4,4a,5,6-hexahydro-1H-pyrazino[1,2-a]quinoline-8-carboxylate