(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone

Base Information

Chemical Name:(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone
CAS No.:1239361-83-1
Molecular Formula:C₂₀H₂₃FN₈O₂S
Molecular Weight:458.519
Hs Code.:

Synonyms:(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone

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Chemical Property of (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone

Chemical Property:

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Technology Process of (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone

There total 4 articles about (S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193269-78-2
3-aminoazetidine-1-carboxylic acid tert-butyl ester

: 1239358-93-0
(S)-6-chloro-N₂-[1-(4-fluorophenyl)ethyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine

: 124-63-0
methanesulfonyl chloride

: 1239361-83-1
(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone

Guidance literature:: 3-aminoazetidine-1-carboxylic acid tert-butyl ester; methanesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Cooling;

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

(S)-6-chloro-N₂-[1-(4-fluorophenyl)ethyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine; With triethylamine; sodium t-butanolate; XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In 1,4-dioxane; at 90 ℃; for 3h; Inert atmosphere;

Reference yield:

: 1056056-12-2
N-(azetidin-3-yl)methanesulfonamide

: 1239358-93-0
(S)-6-chloro-N₂-[1-(4-fluorophenyl)ethyl]-N₄-(pyrazin-2-yl)pyrimidine-2,4-diamine

: 1239361-83-1
(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone

Guidance literature:: With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; triethylamine; sodium t-butanolate; XPhos; In 1,4-dioxane; at 90 ℃; for 3h;

Reference yield:

: 66399-30-2
(S)-1-(4-Fluoro-phenyl)-ethylamine

: 1239361-83-1
(S)-1-{2-[1-(4-fluorophenyl)indolylethylamino]-6-(aminopyrazine-2-ylamino)-4-yl}ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 9.5 h / 20 °C

2: potassium phosphate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 100 °C

3: triethylamine; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; XPhos / 1,4-dioxane / 3 h / 90 °C

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; XPhos; In tetrahydrofuran; 1,4-dioxane;