(2R)-hydroxy(phenyl)acetic acid [(1S)-1-(5-fluoropyridin-2-yl)ethyl]amine

Base Information

Chemical Name:(2R)-hydroxy(phenyl)acetic acid [(1S)-1-(5-fluoropyridin-2-yl)ethyl]amine
CAS No.:1065267-47-1
Molecular Formula:C₇H₉FN₂*C₈H₈O₃
Molecular Weight:292.31
Hs Code.:

Synonyms:(2R)-hydroxy(phenyl)acetic acid [(1S)-1-(5-fluoropyridin-2-yl)ethyl]amine

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Chemical Property of (2R)-hydroxy(phenyl)acetic acid [(1S)-1-(5-fluoropyridin-2-yl)ethyl]amine

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Technology Process of (2R)-hydroxy(phenyl)acetic acid [(1S)-1-(5-fluoropyridin-2-yl)ethyl]amine

There total 4 articles about (2R)-hydroxy(phenyl)acetic acid [(1S)-1-(5-fluoropyridin-2-yl)ethyl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.68%

: 1065267-43-7
[(1S)-1-(5-fluoropyridin-2-yl)ethyl][(1S)-1-phenylethyl]amine 2,3-dihydroxysuccinate

: 611-71-2
(R)-Mandelic Acid

: 1065267-47-1
(2R)-hydroxy(phenyl)acetic acid [(1S)-1-(5-fluoropyridin-2-yl)ethyl]amine

Guidance literature:: [(1S)-1-(5-fluoropyridin-2-yl)ethyl][(1S)-1-phenylethyl]amine 2,3-dihydroxysuccinate; With hydrogen; citric acid; palladium(II) hydroxide/carbon; In methanol; at 50 ℃; for 11h;

With sodium hydroxide; In methanol; water; at 5 - 20 ℃; pH=10 - 12;

(R)-Mandelic Acid; In ethyl acetate; at 25 - 70 ℃; for 1.75 - 1.83333h;

Reference yield:

: 915720-54-6
1-(5-fluoropyridin-2-yl)ethan-1-one

: 1065267-47-1
(2R)-hydroxy(phenyl)acetic acid [(1S)-1-(5-fluoropyridin-2-yl)ethyl]amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 5 h / Heating / reflux

2.1: sodium tetrahydroborate; cerium(III) chloride / methanol / 0.25 h / -45 °C

3.1: ethanol / 18 - 25 °C

4.1: hydrogen; citric acid / palladium(II) hydroxide/carbon / methanol / 11 h / 50 °C

4.2: 5 - 20 °C / pH 10 - 12

4.3: 1.75 - 1.83 h / 25 - 70 °C

With sodium tetrahydroborate; cerium(III) chloride; hydrogen; citric acid; palladium(II) hydroxide/carbon; toluene-4-sulfonic acid; In methanol; ethanol; toluene;

Reference yield:

: [1-(5-fluoropyridin-2-yl)ethyl][(1S)-1-phenylethyl]amine

: 1065267-47-1
(2R)-hydroxy(phenyl)acetic acid [(1S)-1-(5-fluoropyridin-2-yl)ethyl]amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 18 - 25 °C

2.1: hydrogen; citric acid / palladium(II) hydroxide/carbon / methanol / 11 h / 50 °C

2.2: 5 - 20 °C / pH 10 - 12

2.3: 1.75 - 1.83 h / 25 - 70 °C

With hydrogen; citric acid; palladium(II) hydroxide/carbon; In methanol; ethanol;