tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Base Information

Chemical Name:tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane
CAS No.:86031-04-1
Molecular Formula:C₂₉H₃₆O₄Si
Molecular Weight:476.688
Hs Code.:

Synonyms:tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane

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Chemical Property of tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane

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Technology Process of tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane

There total 5 articles about tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 86031-03-0
tert-Butyl-((2S,4R,6R)-2-iodomethyl-6-methoxy-tetrahydro-pyran-4-yloxy)-diphenyl-silane

: 108-95-2,27073-41-2
phenol

: 86031-04-1
tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 52 ℃; for 12h;
DOI:10.1016/S0040-4039(00)85585-9

Reference yield:

: 86030-92-4
methyl 2,4-dideoxy-6-O-(triphenylmethyl)-α-D-erythro-hexopyranoside

: 86031-04-1
tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / 1.)NaH, 2.)t-butyldiphenylsilyl chloride / tetrahydrofuran / 12 h / Ambient temperature

2: MeOH / p-toluenesulfonic acid / 12 h

3: 2.)NaI / 1.)tosylation, 2.)acetone, reflux, 2h

4: 80 percent / K₂CO₃ / dimethylsulfoxide / 12 h / 52 °C

With methanol; sodium hydride; potassium carbonate; tert-butylchlorodiphenylsilane; sodium iodide; toluene-4-sulfonic acid; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)85585-9

Reference yield:

: 86030-93-5
tert-Butyl-((2S,4R,6S)-2-methoxy-6-trityloxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane

: 86031-04-1
tert-Butyl-((2R,4R,6S)-2-methoxy-6-phenoxymethyl-tetrahydro-pyran-4-yloxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: MeOH / p-toluenesulfonic acid / 12 h

2: 2.)NaI / 1.)tosylation, 2.)acetone, reflux, 2h

3: 80 percent / K₂CO₃ / dimethylsulfoxide / 12 h / 52 °C

With methanol; potassium carbonate; sodium iodide; toluene-4-sulfonic acid; In dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)85585-9