2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide

Base Information

Chemical Name:2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide
CAS No.:83604-80-2
Molecular Formula:C₂₉H₃₉ClN₂O₄
Molecular Weight:515.093
Hs Code.:

Synonyms:2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide

Suppliers and Price of 2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide

There total 7 articles about 2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 79-03-8
propionyl chloride

: 83605-06-5
2-{1-[2-(2-Chloro-phenyl)-ethyl]-4-hydroxy-piperidin-4-yl}-N-(2-methoxy-phenyl)-N-propyl-propionamide

: 83604-80-2
2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide

Guidance literature:: With triethylamine; In dichloromethane; for 2h; Heating;
DOI:10.1021/jm00355a010

Reference yield:

: 13078-80-3
2-(2-chlorophenyl)ethanamine

: 83604-80-2
2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide

Guidance literature:: Multi-step reaction with 5 steps

1: 98.7 percent / acetic acid / 6 h / 60 °C

2: Na, propanol / 1 h / Heating

3: conc. HCl / propan-2-ol; H₂O / 6 h / 20 - 130 °C

4: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

5: 59 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

With hydrogenchloride; propan-1-ol; sodium; acetic acid; triethylamine; lithium diisopropyl amide; In dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm00355a010

Reference yield:

: 139944-56-2
N-propyl-2-methoxyaniline

: 83604-80-2
2-<4-(propionyloxy)-1-(2-chlorophenethyl)-4-piperidinyl>-N-(2-methoxyphenyl)-N-propylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CHCl₃ / 1 h / 20 °C

2: 1.) LDA / 1.) THF, hexane, -75 deg C, 20 min, 2.) THF, hexane, -75 deg C, 30 min

3: 59 percent / Et₃N / CH₂Cl₂ / 2 h / Heating

With triethylamine; lithium diisopropyl amide; In dichloromethane; chloroform;
DOI:10.1021/jm00355a010