Technology Process of 1,1-dimethoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]-7,9,11-trimethylheptaleno[4,5-c]furan-3(1H)-one
There total 7 articles about 1,1-dimethoxy-6-[(E)-2-(4-methoxyphenyl)ethenyl]-7,9,11-trimethylheptaleno[4,5-c]furan-3(1H)-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-methyl hydrogen 1-[(E)-2-(4-methoxyphenyl)ethenyl]-6,8,10-trimethylheptalene-4,5-dicarboxylate;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
acetonitrile;
at 0 ℃;
methanol;
In
acetonitrile;
at 20 ℃;
for 1h;
DOI:10.1002/hlca.201300137
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium iodide; triethyl phosphite / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: lithium hydroxide / methanol; water / Reflux
3.1: N,N-dimethyl-formamide; oxalyl dichloride / acetonitrile / 0 °C
3.2: 1 h / 20 °C
With
oxalyl dichloride; N,N-dimethyl-formamide; sodium iodide; lithium hydroxide; triethyl phosphite;
In
tetrahydrofuran; methanol; water; acetonitrile;
1.1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1002/hlca.201300137
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene / 6 h / 130 °C
1.2: 1 h / 120 °C
2.1: hexachloroethane; potassium tert-butylate / tetrahydrofuran / -78 °C / Inert atmosphere
3.1: sodium iodide / 3 h / 130 °C
4.1: sodium iodide; triethyl phosphite / tetrahydrofuran / 20 °C / Inert atmosphere
5.1: lithium hydroxide / methanol; water / Reflux
6.1: N,N-dimethyl-formamide; oxalyl dichloride / acetonitrile / 0 °C
6.2: 1 h / 20 °C
With
oxalyl dichloride; hexachloroethane; potassium tert-butylate; N,N-dimethyl-formamide; sodium iodide; lithium hydroxide; triethyl phosphite;
In
tetrahydrofuran; methanol; water; toluene; acetonitrile;
3.1: |Arbuzov Reaction / 4.1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1002/hlca.201300137
