toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester
• CAS No.: 244126-24-7
• Molecular Formula: C₁₅H₁₅BrO₄S
• Molecular Weight: 371.252
• Mol file: 244126-24-7.mol

Synonyms:toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester

Chemical Property of toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester

There total 5 articles about toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

toluene-4-sulfonic acid 5-bromo-2-hydroxy-3-methyl-phenyl ester (244126-23-6) + methyl iodide (74-88-4) → toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester (244126-24-7)

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1055/s-1999-3161

Reference yield:

3-methylbenzene-1,2-diol (488-17-5) → toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester (244126-24-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / TEA / CH₂Cl₂ / 0 °C

2: 97 percent / Br₂; AcOH / CH₂Cl₂ / 0.5 h / 20 °C

3: 96 percent / K₂CO₃ / acetone / 1 h / Heating

With TEA; bromine; potassium carbonate; acetic acid; In dichloromethane; acetone;

DOI:10.1021/ja026216d

Reference yield:

toluene-4-sulfonic acid 2-hydroxy-3-methyl-phenyl ester (244126-22-5) → toluene-4-sulfonic acid 5-bromo-2-methoxy-3-methyl-phenyl ester (244126-24-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / Br₂; AcOH / CH₂Cl₂ / 0.5 h / 20 °C

2: 96 percent / K₂CO₃ / acetone / 1 h / Heating

With bromine; potassium carbonate; acetic acid; In dichloromethane; acetone;

DOI:10.1021/ja026216d

upstream raw materials:

toluene-4-sulfonic acid 5-bromo-2-hydroxy-3-methyl-phenyl ester

methyl iodide

p-toluenesulfonyl chloride

3-methylbenzene-1,2-diol

Downstream raw materials:

(1R,9S,10R,11R,12R)-12-Azido-11-benzyloxy-6-bromo-4-methoxy-5-methyl-13-(toluene-4-sulfonyl)-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-3,10-diol

(1R,9S,10R,11R,12R)-12-Azido-11-benzyloxy-6-bromo-3,4-dimethoxy-5-methyl-13-(toluene-4-sulfonyl)-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-trien-10-ol

(1R,9S,10R,11R,12R)-12-Azido-6-bromo-3,4-dimethoxy-5-methyl-13-(toluene-4-sulfonyl)-13-aza-tricyclo[7.3.1.0^2,7]trideca-2⁽⁷⁾,3,5-triene-10,11-diol

C₂₄H₂₅BrN₂O₇S