N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

Base Information

Chemical Name:N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide
CAS No.:205500-32-9
Molecular Formula:C₃₄H₅₁N₅O₆Si₃
Molecular Weight:710.065
Hs Code.:

N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

Synonyms:N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

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Chemical Property of N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

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Technology Process of N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

There total 2 articles about N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 100034-54-6
N-[9-((2R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-oxo-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

: 1066-54-2
trimethylsilylacetylene

: 205500-32-9
N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1016/S0960-894X(98)00060-2

Reference yield:

: 79154-57-7
3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-N₆-benzoyladenosine

: 205500-32-9
N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / Dess-Martin periodinane / CH₂Cl₂ / 20 h / Ambient temperature

2: 95 percent / BuLi / tetrahydrofuran / 3 h / -78 °C

With n-butyllithium; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(98)00060-2

Reference yield:

: 205500-32-9
N-[9-((2R,3aR,9aR)-3-Hydroxy-5,5,7,7-tetraisopropyl-3-trimethylsilanylethynyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-9H-purin-6-yl]-benzamide

: 205500-34-1
9-{2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-C-[(trimethylsilyl)ethynyl]-β-D-arabinofuranosyl}-N⁶-(phenoxyacetyl)adenine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) CH₃O₂CCOCl, DMAP, 2.) Bu₃SnH, AIBN / 1.) CH₂Cl₂, RT, 12 h, 2.) toluene, 90 deg C, 4 h

2: 1.) Et₃O⁺BF₄^- / 1.) CH₂Cl₂, RT, 3h, 2.) CH₂Cl₂, RT, 19h

With monomethyl oxalyl chloride; dmap; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; triethyloxonium fluoroborate;
DOI:10.1016/S0960-894X(98)00060-2