C₂₅H₁₉Br₂N₃O₃

Base Information

• Chemical Name: C₂₅H₁₉Br₂N₃O₃
• CAS No.: 1394289-63-4
• Molecular Formula: C₂₅H₁₉Br₂N₃O₃
• Molecular Weight: 569.252
• Mol file: 1394289-63-4.mol

Synonyms:C₂₅H₁₉Br₂N₃O₃

Chemical Property of C₂₅H₁₉Br₂N₃O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₁₉Br₂N₃O₃

There total 3 articles about C₂₅H₁₉Br₂N₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C18H16BrN3O3 (1394289-44-1) + 4-bromo-benzaldehyde (1122-91-4) → C25H19Br2N3O3 (1394289-63-4)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 4h; stereoselective reaction;

DOI:10.1016/j.bmc.2012.07.009

Reference yield:

1-(2-hydroxy-4-prop-2-ynyloxy-phenyl)-ethanone (67091-10-5) → C25H19Br2N3O3 (1394289-63-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 4 h / 20 °C

2: potassium hydroxide / ethanol / 4 h / 20 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; potassium hydroxide; In ethanol; water; tert-butyl alcohol; 2: |Claisen-Schmidt Condensation;

DOI:10.1016/j.bmc.2012.07.009

Reference yield:

2',4'-dihydroxy-4-acetophenone (89-84-9) → C25H19Br2N3O3 (1394289-63-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; tetrabutylammomium bromide / 6 h / 20 °C

2: sodium L-ascorbate; copper(ll) sulfate pentahydrate / tert-butyl alcohol; water / 4 h / 20 °C

3: potassium hydroxide / ethanol / 4 h / 20 °C

With copper(ll) sulfate pentahydrate; tetrabutylammomium bromide; potassium carbonate; sodium L-ascorbate; potassium hydroxide; In ethanol; water; tert-butyl alcohol; 3: |Claisen-Schmidt Condensation;

DOI:10.1016/j.bmc.2012.07.009

upstream raw materials:

C₁₈H₁₆BrN₃O₃

4-bromo-benzaldehyde

1-(2-hydroxy-4-prop-2-ynyloxy-phenyl)-ethanone

2',4'-dihydroxy-4-acetophenone

Downstream raw materials:

C₂₅H₁₉Br₂N₃O₃

2-{2-amino-6-(4-bromophenyl)pyrimidin-4-yl}-5-{{1-(4-bromobenzyl)-1H-1,2,3-triazol-4-yl}methoxy}phenol