Technology Process of (S)-tert-butyl 5-oxo-3,5-diphenylpentanoate
There total 4 articles about (S)-tert-butyl 5-oxo-3,5-diphenylpentanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
cis-Hyp(tBu)-Thr(tBu)-TentaGel;
In
tetrahydrofuran;
for 6h;
optical yield given as %ee;
enantioselective reaction;
Cooling;
DOI:10.1002/anie.200801811
- Guidance literature:
-
With
potassium osmate(VI) dihydrate; sodium periodate;
In
water; tert-butyl alcohol;
for 16h;
DOI:10.1021/ol401007u
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 2 h / Inert atmosphere
2.1: dmap / tert-butyl alcohol / 1 h / 20 °C / Inert atmosphere
3.1: sodium periodate; potassium osmate(VI) dihydrate / water; tert-butyl alcohol / 16 h
With
dmap; potassium osmate(VI) dihydrate; sodium periodate; potassium tert-butylate;
In
tetrahydrofuran; water; tert-butyl alcohol;
DOI:10.1021/ol401007u
