Technology Process of N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}-N-ethylacetamide
There total 12 articles about N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}-N-ethylacetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid; sodium hydrogensulfite;
In
N,N-dimethyl acetamide;
at 150 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: dimethyl sulfoxide / 48 h / 120 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0.08 h / Inert atmosphere
3.1: sodium azide / N,N-dimethyl-formamide / 5 h / 80 °C
4.1: acetic acid; palladium 10% on activated carbon; hydrogen / 1,4-dioxane; water / 5 h / 760.05 Torr
5.1: triethylamine / dichloromethane / 0.08 h / 20 °C
6.1: diisobutylaluminium hydride / dichloromethane; hexane / 1.33 h / -78 - 20 °C / Inert atmosphere
7.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 19 h / 20 °C / Molecular sieve
8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.58 h / 0 °C
8.2: 2 h / 0 - 20 °C
9.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 4 h / 150 °C
With
sodium azide; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; acetic acid; 4-methylmorpholine N-oxide; triethylamine;
In
1,4-dioxane; hexane; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: dimethyl sulfoxide / 48 h / 120 °C / Inert atmosphere
2.1: triethylamine / dichloromethane / 0.08 h / Inert atmosphere
3.1: sodium azide / N,N-dimethyl-formamide / 5 h / 80 °C
4.1: acetic acid; palladium 10% on activated carbon; hydrogen / 1,4-dioxane; water / 5 h / 760.05 Torr
5.1: triethylamine / dichloromethane / 0.08 h / 20 °C
6.1: diisobutylaluminium hydride / dichloromethane; hexane / 1.33 h / -78 - 20 °C / Inert atmosphere
7.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 19 h / 20 °C / Molecular sieve
8.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.58 h / 0 °C
8.2: 2 h / 0 - 20 °C
9.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 4 h / 150 °C
With
sodium azide; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; sodium hydride; diisobutylaluminium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; acetic acid; 4-methylmorpholine N-oxide; triethylamine;
In
1,4-dioxane; hexane; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
