methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Base Information

Chemical Name:methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate
CAS No.:1403382-27-3
Molecular Formula:C₂₆H₂₃F₃O₅
Molecular Weight:472.461
Hs Code.:

Synonyms:methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

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Chemical Property of methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

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Technology Process of methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

There total 12 articles about methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1403382-26-2
methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-oxoacetate

: 1403382-27-3
methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: With methanol; sodium tetrahydroborate; at 0 - 20 ℃; for 1h;

Reference yield:

: 1403382-22-8
ethyl 2-{3-fluoro-2-[(trifluoromethane) sulfonyloxy]-6-(trifluoromethyl)phenyl)-2-oxoacetate

: 1403382-27-3
methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C

1.2: 0.25 h / 0 - 20 °C

2.1: sodium hydride / ISOPROPYLAMIDE; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 20 °C

2.3: 0.33 h / 0 - 20 °C

3.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; sodium hydride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ISOPROPYLAMIDE; water; mineral oil;

Reference yield:

: 141483-15-0
2-fluoro-5-trifluoromethylphenol

: 1403382-27-3
methyl 2-[3-(benzyloxy)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]-2-hydroxyacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

2.1: potassium tert-butylate; n-butyllithium / hexane; tetrahydrofuran / 2 h / -78 °C / Inert atmosphere

2.2: 0.75 h / -78 °C

3.1: toluene-4-sulfonic acid / dichloromethane; ethanol / 50 °C

4.1: triethylamine / dichloromethane / 0.75 h / -78 °C / Inert atmosphere

5.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 85 °C

5.2: 0.25 h / 0 - 20 °C

6.1: sodium hydride / ISOPROPYLAMIDE; mineral oil / 0.5 h / 0 - 20 °C / Inert atmosphere

6.2: 4 h / 20 °C

6.3: 0.33 h / 0 - 20 °C

7.1: sodium tetrahydroborate; methanol / 1 h / 0 - 20 °C

With methanol; sodium tetrahydroborate; n-butyllithium; potassium tert-butylate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; ISOPROPYLAMIDE; water; mineral oil;