6-amino-1-(4-chlorophenyl)-4-(methylthio)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

Base Information

Chemical Name:6-amino-1-(4-chlorophenyl)-4-(methylthio)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile
CAS No.:325844-72-2
Molecular Formula:C₁₄H₉ClN₄OS
Molecular Weight:316.771
Hs Code.:

Synonyms:6-amino-1-(4-chlorophenyl)-4-(methylthio)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-amino-1-(4-chlorophenyl)-4-(methylthio)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

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Technology Process of 6-amino-1-(4-chlorophenyl)-4-(methylthio)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

There total 6 articles about 6-amino-1-(4-chlorophenyl)-4-(methylthio)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 17722-17-7
N-(4-chlorophenyl)-2-cyanoacetamide

: 5147-80-8
[Bis(methylthio)methylene]malononitrile

: 325844-72-2
6-amino-1-(4-chlorophenyl)-4-(methylthio)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

Guidance literature:: With sodium ethanolate; In ethanol; for 3h; Heating;
DOI:10.1080/10426500008045245

Reference yield:

: 6-amino-1-(4-chlorophenyl)-4-mercapto-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

: 74-88-4
methyl iodide

: 325844-72-2
6-amino-1-(4-chlorophenyl)-4-(methylthio)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

Guidance literature:: 6-amino-1-(4-chlorophenyl)-4-mercapto-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile; With sodium ethanolate; In ethanol; at 50 ℃; for 0.5h;

methyl iodide; In ethanol; at 20 ℃; for 3h; Reflux;
DOI:10.1080/15257770.2015.1071843

Reference yield:

: 17722-17-7
N-(4-chlorophenyl)-2-cyanoacetamide

: 325844-72-2
6-amino-1-(4-chlorophenyl)-4-(methylthio)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethoxide / ethanol

1.2: 89 percent / ethanol / 2 h / 20 °C

2.1: sodium ethoxide / ethanol / 0.5 h / Heating

3.1: piperidine / ethanol / 0.5 h / Heating

With piperidine; sodium ethanolate; In ethanol;
DOI:10.1080/00397910500449500