trans-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

Base Information

Chemical Name:trans-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol
CAS No.:1611452-67-5
Molecular Formula:C₂₂H₂₉N₃O₂
Molecular Weight:367.491
Hs Code.:

Synonyms:trans-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

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Chemical Property of trans-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

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Technology Process of trans-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

There total 7 articles about trans-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1611452-35-7
4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanone

: 75-16-1
methylmagnesium bromide

: 1611452-66-4
cis-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

: 1611452-67-5
trans-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

Guidance literature:: In tetrahydrofuran; at -20 - 20 ℃; for 12h;

Reference yield:

: 680596-79-6
4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane

: 1611452-66-4
cis-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

: 1611452-67-5
trans-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 16 h / 100 °C

2: hydrogen; palladium on activated charcoal / methanol / 20 °C

3: triphenylphosphine / tetrahydrofuran / 0.17 h / 0 - 20 °C

4: trifluoroacetic acid / 0.5 h / 20 °C

5: tetrahydrofuran / 12 h / -20 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; hydrogen; potassium carbonate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

: 1611453-18-9
2-methyl-5-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)pyrimidin-4-ol

: 1611452-66-4
cis-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

: 1611452-67-5
trans-1-methyl-4-(2-methyl-4-(((1S,2S)-2-(5-methylpyridin-2-yl)cyclopropyl)methoxy)pyrimidin-5-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen; palladium on activated charcoal / methanol / 20 °C

2: triphenylphosphine / tetrahydrofuran / 0.17 h / 0 - 20 °C

3: trifluoroacetic acid / 0.5 h / 20 °C

4: tetrahydrofuran / 12 h / -20 - 20 °C

With palladium on activated charcoal; hydrogen; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; methanol;