6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-trimethylsilanylethynylphenyl)amino]nicotinate

Base Information

Chemical Name:6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-trimethylsilanylethynylphenyl)amino]nicotinate
CAS No.:1337469-45-0
Molecular Formula:C₂₇H₃₈N₂O₃Si
Molecular Weight:466.696
Hs Code.:

Synonyms:6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-trimethylsilanylethynylphenyl)amino]nicotinate

Suppliers and Price of 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-trimethylsilanylethynylphenyl)amino]nicotinate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-trimethylsilanylethynylphenyl)amino]nicotinate

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Technology Process of 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-trimethylsilanylethynylphenyl)amino]nicotinate

There total 2 articles about 6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-trimethylsilanylethynylphenyl)amino]nicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1337469-43-8
methyl 6-[N-ethyl-N-(2-iodo-5-isobutoxy-4-isopropylphenyl)amino]nicotinate

: 1066-54-2
trimethylsilylacetylene

: 1337469-45-0
6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-trimethylsilanylethynylphenyl)amino]nicotinate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 10h; Inert atmosphere;
DOI:10.1021/ml200197e

Reference yield:

: 1055233-46-9
methyl 6-[N-ethyl-N-(3-isobutoxy-4-isopropylphenyl)amino]nicotinate

: 1337469-45-0
6-[N-ethyl-N-(5-isobutoxy-4-isopropyl-2-trimethylsilanylethynylphenyl)amino]nicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; silver sulfate / methanol / 11 h / 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 10 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; silver sulfate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/ml200197e