2,4-DIFLUORO-5-METHYLBENZOIC ACID METHYL ESTER

Base Information

• Chemical Name: 2,4-DIFLUORO-5-METHYLBENZOIC ACID METHYL ESTER
• CAS No.: 1162674-66-9
• Molecular Formula: C₉H₈F₂O₂
• Molecular Weight: 186.158
• Mol file: 1162674-66-9.mol

Synonyms:2,4-difluoro-5-methyl-benzoic acid methyl ester

Chemical Property of 2,4-DIFLUORO-5-METHYLBENZOIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 227.0±40.0 °C(Predicted)
• Density: 1.224±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2,4-Difluoro-5-methyl-benzoicacidmethylester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DIFLUORO-5-METHYLBENZOIC ACID METHYL ESTER

There total 1 articles about 2,4-DIFLUORO-5-METHYLBENZOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,4-Difluoro-5-methylbenzoic acid (367954-99-2) → 2,4-difluoro-5-methyl-benzoic acid methyl ester (1162674-66-9)

Guidance literature:

With thionyl chloride; In methanol; at 50 ℃; for 3h; Cooling with ice;

Reference yield: 100.0%

2,4-difluoro-5-methyl-benzoic acid methyl ester (1162674-66-9) → (2,4-difluoro-5-methyl-phenyl)-methanol (315204-46-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; for 2h; Cooling with acetone-dry ice;

Reference yield:

2,4-difluoro-5-methyl-benzoic acid methyl ester (1162674-66-9) → 5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one (1442451-91-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -78 °C / Cooling with acetone-dry ice

2: thionyl chloride / dichloromethane / 3 h / 60 °C / Cooling with ice

3: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide / 5 h / 60 °C

With lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2,4-Difluoro-5-methylbenzoic acid

Downstream raw materials:

1-chloromethyl-2,4-difluoro-5-methyl-benzene

5-chloro-6-((2,4-difluoro-5-methylbenzyl)oxy)-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methylpyrimidin-4(3H)-one

(2,4-difluoro-5-methyl-phenyl)-methanol

Refernces