2-(Chloroacetyl)thiophene

Base Information

• Chemical Name: 2-(Chloroacetyl)thiophene
• CAS No.: 29683-77-0
• Molecular Formula: C6H5ClOS
• Molecular Weight: 160.624
• Hs Code.: 2934208090
• DSSTox Substance ID: DTXSID80374074
• Nikkaji Number: J718.120E
• Wikidata: Q82162554
• ChEMBL ID: CHEMBL359135
• Mol file: 29683-77-0.mol

Synonyms:29683-77-0;2-(chloroacetyl)thiophene;2-chloro-1-thiophen-2-ylethanone;2-chloro-1-(thiophen-2-yl)ethan-1-one;2-chloro-1-(thiophen-2-yl)ethanone;2-Chloro-1-thien-2-ylethanone;2-(Chloroacetyl)thiophene (>85per cent);2-Chloro-1-thiophen-2-yl-ethanone;MFCD01812507;Ethanone, 2-chloro-1-(2-thienyl)-;2-chloro-1-(2-thienyl)ethanone;2-chloroacetylthiophene;starbld0000312;2-alpha-chloroacetylthiophene;Chloromethyl 2-thienyl ketone;SCHEMBL230036;omega-chloro-2-acetylthiophene;2-thienylcarbonylmethyl chloride;BDBM7858;CHEMBL359135;DTXSID80374074;KHOWLHQEABZKNA-UHFFFAOYSA-N;2-(Chloroacetyl)thiophene (>85%);Chloromethyl Thienyl Ketone deriv. 6;2-chloranyl-1-thiophen-2-yl-ethanone;2-chloro-1-(thiophen-2- yl)ethanone;AKOS000159612;2-chloro-1-(thiphen-2-yl)-1-ethanone;NS-01258;CS-0239288;FT-0608750;EN300-208889;A820011;J-017604;Z285150724

Chemical Property of 2-(Chloroacetyl)thiophene

Chemical Property:

• Appearance/Colour: White Solid
• Vapor Pressure: 0.00936mmHg at 25°C
• Melting Point: 45 °C
• Refractive Index: 1.562
• Boiling Point: 265.1 °C at 760 mmHg
• Flash Point: 114.1 °C
• Density: 1.318 g/cm³
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 159.9749636
• Heavy Atom Count: 9
• Complexity: 116

Purity/Quality:

97% ^*data from raw suppliers

2-(Chloroacetyl)thiophene(>85%) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)C(=O)CCl
• Uses: 2-(Chloroacetyl)thiophene (>85%) (cas# 29683-77-0) is a compound useful in organic synthesis.

Technology Process of 2-(Chloroacetyl)thiophene

There total 12 articles about 2-(Chloroacetyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Acetylthiophene (88-15-3,97511-16-5) → 2-chloro-1-(thiophen-2-yl)ethanone (29683-77-0)

Guidance literature:

With N,N,N-trimethylbenzenemethanaminium dichloroiodate; In methanol; 1,2-dichloro-ethane; for 3h; Heating;

DOI:10.1055/s-1988-27633

Reference yield: 85.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) + chloroacetyl chloride (79-04-9) → 2-chloro-1-(thiophen-2-yl)ethanone (29683-77-0)

Guidance literature:

With aluminium trichloride; In carbon disulfide;

DOI:10.3987/R-1987-10-2599

Reference yield: 77.0%

[[2-chloro-1-(2-thienyl)ethenyl]oxy]tri-isopropylsilane (556025-94-6) → 2-chloro-1-(thiophen-2-yl)ethanone (29683-77-0)

Guidance literature:

With hydrogen fluoride; In acetonitrile; for 2h;

DOI:10.1016/j.tetasy.2006.07.017

upstream raw materials:

thiophene

chloroacetyl chloride

2-Acetylthiophene

trimethyl((1-(thiophen-2-yl)vinyl)oxy)silane

Downstream raw materials:

2-(thiophen-2-yl)imidazo[1,2-a]pyridine

dimethyl-(2-oxo-2-[2]thienyl-ethyl)-phenacyl-ammonium; chloride

2-phenyl-4-(2-thienyl)-thiazole

bis<2-oxo-2-(2-thienyl)ethyl> sulfide