Thiazole, 2-phenyl-4-(2-thienyl)-

Base Information

• Chemical Name: Thiazole, 2-phenyl-4-(2-thienyl)-
• CAS No.: 113214-23-6
• Molecular Formula: C13H9NS2
• Molecular Weight: 243.353
• DSSTox Substance ID: DTXSID80383808
• Nikkaji Number: J2.642.081D
• Wikidata: Q82175603
• Mol file: 113214-23-6.mol

Synonyms:Thiazole, 2-phenyl-4-(2-thienyl)-;113214-23-6;Maybridge1_000487;SCHEMBL13930885;HMS542O03;DTXSID80383808;2-Phenyl-4-(2-thienyl)thiazole;AKOS005139718;AW 00436

Chemical Property of Thiazole, 2-phenyl-4-(2-thienyl)-

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 243.01764164
• Heavy Atom Count: 16
• Complexity: 228

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=NC(=CS2)C3=CC=CS3

Technology Process of Thiazole, 2-phenyl-4-(2-thienyl)-

There total 6 articles about Thiazole, 2-phenyl-4-(2-thienyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-iodo-2-phenylthiazole + 2-thiopheneboronic acid pinacol ester (193978-23-3) → 2-phenyl-4-(2-thienyl)-thiazole (113214-23-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 16h;

DOI:10.1016/j.tet.2010.07.081

Reference yield: 58.0%

2-chloro-1-(thiophen-2-yl)ethanone (29683-77-0) + benzenecarbothioamide (2227-79-4) → 2-phenyl-4-(2-thienyl)-thiazole (113214-23-6)

Guidance literature:

In ethanol; Heating;

Reference yield: 51.0%

2-bromothiophene (1003-09-4) + 2-phenyl-4-(tributylstannyl)thiazole → 2-phenyl-4-(2-thienyl)-thiazole (113214-23-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In toluene; for 24h; Reflux;

DOI:10.1016/j.tet.2010.07.081

upstream raw materials:

2-chloro-1-(thiophen-2-yl)ethanone

benzenecarbothioamide

2-bromothiophene

4-bromo-2-phenylthiazole