dimethyl 1-diazo-3-methoxy-4-methyl-2-oxo-4-phenyl-3(E)-butenylphosphonate

Base Information

Chemical Name:dimethyl 1-diazo-3-methoxy-4-methyl-2-oxo-4-phenyl-3(E)-butenylphosphonate
CAS No.:177979-41-8
Molecular Formula:C₁₄H₁₇N₂O₅P
Molecular Weight:324.273
Hs Code.:

Synonyms:dimethyl 1-diazo-3-methoxy-4-methyl-2-oxo-4-phenyl-3(E)-butenylphosphonate

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Chemical Property of dimethyl 1-diazo-3-methoxy-4-methyl-2-oxo-4-phenyl-3(E)-butenylphosphonate

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Technology Process of dimethyl 1-diazo-3-methoxy-4-methyl-2-oxo-4-phenyl-3(E)-butenylphosphonate

There total 3 articles about dimethyl 1-diazo-3-methoxy-4-methyl-2-oxo-4-phenyl-3(E)-butenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: ((E)-3-Methoxy-2-oxo-4-phenyl-pent-3-enyl)-phosphonic acid dimethyl ester

: 177979-41-8
dimethyl 1-diazo-3-methoxy-4-methyl-2-oxo-4-phenyl-3(E)-butenylphosphonate

Guidance literature:: With 4-toluenesulfonyl azide; potassium carbonate; In acetonitrile; Ambient temperature;
DOI:10.1016/0040-4020(96)00318-3

Reference yield:

: 98-86-2
acetophenone

: 177979-41-8
dimethyl 1-diazo-3-methoxy-4-methyl-2-oxo-4-phenyl-3(E)-butenylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1 M LHMDS / 1.) THF, from -40 deg C to 5 deg C, 2.) THF, RT, 3 h

2: 1.) n-BuLi / 1.) THF, hexane, -80 deg C, 45 min, 2.) THF, RT, 3 h

3: 86 percent / tosyl azide, K₂CO₃ / acetonitrile / Ambient temperature

With n-butyllithium; 4-toluenesulfonyl azide; potassium carbonate; lithium hexamethyldisilazane; In acetonitrile;
DOI:10.1016/0040-4020(96)00318-3

Reference yield:

: 177979-35-0
methyl 2-methoxy-3-methyl-3-phenyl-2(E)-propenoate

: 177979-41-8
dimethyl 1-diazo-3-methoxy-4-methyl-2-oxo-4-phenyl-3(E)-butenylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -80 deg C, 45 min, 2.) THF, RT, 3 h

2: 86 percent / tosyl azide, K₂CO₃ / acetonitrile / Ambient temperature

With n-butyllithium; 4-toluenesulfonyl azide; potassium carbonate; In acetonitrile;
DOI:10.1016/0040-4020(96)00318-3