(3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

Base Information

Chemical Name:(3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one
CAS No.:204914-69-2
Molecular Formula:C₁₇H₂₁NO₂
Molecular Weight:271.359
Hs Code.:

Synonyms:(3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

Suppliers and Price of (3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

There total 1 articles about (3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103201-79-2,1820583-17-2
(3R,7aS)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

: 870-63-3
prenyl bromide

: 204914-68-1
(3R,6R,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

: 204914-69-2
(3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, heptane, benzene, -78 deg C, 30 min, 2.) THF, heptane, benzene, -78 deg C, 15 min;
DOI:10.1021/ja972494e

Reference yield:

: 204914-69-2
(3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

: (2S,4S)-1-[(2S,4S)-1-[(2S,4S)-1-(2,2-Dimethyl-propionyl)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-4-(3-methyl-butyl)-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: LAH / tetrahydrofuran / 1 h / Heating

2: H₂ / 10percent Pd/C / acetic acid; ethanol / 3 h / 3102.9 Torr

3: CH₂Cl₂

4: 1.) CrO₃, H₂SO₄, 2.) H₂ / 2.) 10percent Pd/C / 1.) acetone, 0 deg C, 1 h, 2.) acetone, 1 atm

5: DIC, HOBt, DMAP, Et₃N / CH₂Cl₂

6: HCl, AcOH / 1 h / Ambient temperature

7: Et₃N / CH₂Cl₂ / 0.25 h

8: H₂ / Pd/C / ethyl acetate / 6 h

9: DIC, Et₃N / CH₂Cl₂ / Ambient temperature

With chromium(VI) oxide; hydrogenchloride; dmap; lithium aluminium tetrahydride; sulfuric acid; hydrogen; benzotriazol-1-ol; acetic acid; dacarbazine; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; ethyl acetate;
DOI:10.1021/ja972494e

Reference yield:

: 204914-69-2
(3R,6S,7aS)-6-(3-Methyl-but-2-enyl)-3-phenyl-tetrahydro-pyrrolo[1,2-c]oxazol-5-one

: (2S,4S)-4-(3-Methyl-butyl)-1-[(2S,4S)-4-(3-methyl-butyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: LAH / tetrahydrofuran / 1 h / Heating

2: H₂ / 10percent Pd/C / acetic acid; ethanol / 3 h / 3102.9 Torr

3: CH₂Cl₂

4: 1.) CrO₃, H₂SO₄, 2.) H₂ / 2.) 10percent Pd/C / 1.) acetone, 0 deg C, 1 h, 2.) acetone, 1 atm

5: DIC, HOBt, DMAP, Et₃N / CH₂Cl₂

6: HCl, AcOH / 1 h / Ambient temperature

With chromium(VI) oxide; hydrogenchloride; dmap; lithium aluminium tetrahydride; sulfuric acid; hydrogen; benzotriazol-1-ol; acetic acid; dacarbazine; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/ja972494e