(4-Methoxypyridin-3-yl)methanol

Base Information

• Chemical Name: (4-Methoxypyridin-3-yl)methanol
• CAS No.: 120277-47-6
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.154
• European Community (EC) Number: 834-995-5
• DSSTox Substance ID: DTXSID301309648
• Nikkaji Number: J2.260.521F
• Mol file: 120277-47-6.mol

Synonyms:(4-methoxypyridin-3-yl)methanol;120277-47-6;3-Pyridinemethanol, 4-methoxy-;3-Pyridinemethanol,4-methoxy-(9CI);4-Methoxypyridine-3-methanol;(4-methoxy-pyridin-3-yl)-methanol;4-methoxy-3-pyridinemethanol;3-pyridinemethanol,4-methoxy-;SCHEMBL1770449;OUNUFEHYGMCMEM-UHFFFAOYSA-N;DTXSID301309648;AMY17098;VEA27747;MFCD11100741;AKOS006308959;AB87833;AS-41023;CS-0142299;EN300-120202;Z1198311138

Chemical Property of (4-Methoxypyridin-3-yl)methanol

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 268.65°C at 760 mmHg
• Flash Point: 116.275°C
• PSA: 42.35000
• Density: 1.155g/cm³
• LogP: 0.58250
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

98% ^*data from raw suppliers

(4-Methoxypyridin-3-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=NC=C1)CO

Technology Process of (4-Methoxypyridin-3-yl)methanol

There total 7 articles about (4-Methoxypyridin-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 4-methoxynicotinate (10177-32-9) → 3-hydroxymethyl-4-methoxypyridine (120277-47-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 0.333333h; Heating;

DOI:10.1080/00397919608004536

Reference yield:

3-picoline-N-oxide (1003-73-2) → 3-hydroxymethyl-4-methoxypyridine (120277-47-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 51 percent / HNO₃, H₂SO₄ / 2 h

2: 97 percent / HCl, PCl₃ / CHCl₃ / 0.33 h / Heating

3: 65 percent / KMnO₄ / H₂O / 4 h / 80 - 90 °C

4: 63 percent / HCl / 3 h / Heating

5: 96 percent / LiAlH₄ / diethyl ether / 0.33 h / Heating

With hydrogenchloride; potassium permanganate; lithium aluminium tetrahydride; sulfuric acid; nitric acid; phosphorus trichloride; In diethyl ether; chloroform; water;

DOI:10.1080/00397919608004536

Reference yield:

4-chloro-3-methylpyridine (1681-36-3) → 3-hydroxymethyl-4-methoxypyridine (120277-47-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / KMnO₄ / H₂O / 4 h / 80 - 90 °C

2: 63 percent / HCl / 3 h / Heating

3: 96 percent / LiAlH₄ / diethyl ether / 0.33 h / Heating

With hydrogenchloride; potassium permanganate; lithium aluminium tetrahydride; In diethyl ether; water;

DOI:10.1080/00397919608004536

upstream raw materials:

methyl 4-methoxynicotinate

4-methoxynicotinaldehyde

4-methoxypyridine

3-picoline-N-oxide

Refernces

• 1、 Leroy,Despres,Bigan,Blondeau. "Syntheses of ortho-hydroxymethylpyridinols and dioxaphosphorino[m,n-x]pyridines". . p. 2257 - 2272. Retrieved 2007/10/03.