dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-3-O-methyl-L-glycero-L-talo-heptit-1-yl phosphonate

Base Information

Chemical Name:dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-3-O-methyl-L-glycero-L-talo-heptit-1-yl phosphonate
CAS No.:871116-43-7
Molecular Formula:C₂₄H₃₃O₇P
Molecular Weight:464.496
Hs Code.:

Synonyms:dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-3-O-methyl-L-glycero-L-talo-heptit-1-yl phosphonate

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Chemical Property of dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-3-O-methyl-L-glycero-L-talo-heptit-1-yl phosphonate

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Technology Process of dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-3-O-methyl-L-glycero-L-talo-heptit-1-yl phosphonate

There total 5 articles about dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-3-O-methyl-L-glycero-L-talo-heptit-1-yl phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 871116-42-6
dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-L-glycero-L-talo-heptit-1-yl phosphonate

: 74-88-4
methyl iodide

: 871116-43-7
dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-3-O-methyl-L-glycero-L-talo-heptit-1-yl phosphonate

Guidance literature:: With silver(l) oxide; In N,N-dimethyl-formamide; at 20 ℃; for 72h;
DOI:10.1002/ejoc.200500440

Reference yield:

: 3,4-di-O-benzyl-2-O-p-methoxybenzyl-L-rhamnopyranose

: 871116-43-7
dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-3-O-methyl-L-glycero-L-talo-heptit-1-yl phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / NaH / 1,2-dimethoxy-ethane / 48 h / 20 °C

2: 0.74 g / DDQ / CH₂Cl₂; H₂O / 2 h / 20 °C

3: 70 percent / Ag₂O / dimethylformamide / 72 h / 20 °C

With sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200500440

Reference yield:

: 871116-39-1
allyl 3,4-di-O-benzyl-2-O-p-methoxybenzyl-α-L-rhamnopyranoside

: 871116-43-7
dimethyl 2,6-anhydro-1,7-dideoxy-4,5-di-O-benzyl-3-O-methyl-L-glycero-L-talo-heptit-1-yl phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tBuOK / dimethylsulfoxide / 3 h

1.2: 96 percent / pyridine; I₂ / CHCl₃ / 3 h / 20 °C

2.1: 87 percent / NaH / 1,2-dimethoxy-ethane / 48 h / 20 °C

3.1: 0.74 g / DDQ / CH₂Cl₂; H₂O / 2 h / 20 °C

4.1: 70 percent / Ag₂O / dimethylformamide / 72 h / 20 °C

With potassium tert-butylate; sodium hydride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; silver(l) oxide; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200500440