5-(1-acetoxy-2-tert-butoxycarbonyl-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-(1-acetoxy-2-tert-butoxycarbonyl-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester
• CAS No.: 811446-73-8
• Molecular Formula: C₂₁H₂₁Cl₂NO₇
• Molecular Weight: 470.306

Synonyms:5-(1-acetoxy-2-tert-butoxycarbonyl-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester

Chemical Property of 5-(1-acetoxy-2-tert-butoxycarbonyl-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 5-(1-acetoxy-2-tert-butoxycarbonyl-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester

There total 3 articles about 5-(1-acetoxy-2-tert-butoxycarbonyl-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

acetyl chloride (75-36-5) + 5-(2-tert-butoxycarbonyl-1-hydroxy-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester (811446-63-6) → 5-(1-acetoxy-2-tert-butoxycarbonyl-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester (811446-73-8)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃; for 0.0833333h;

DOI:10.1055/s-2004-831179

Reference yield:

tert-Butyl acrylate (1663-39-4,25232-27-3) → 5-(1-acetoxy-2-tert-butoxycarbonyl-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester (811446-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / DABCO / tetrahydrofuran / 0.08 h / 20 °C

2: 90 percent / pyridine / CH₂Cl₂ / 0.08 h / 0 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; dichloromethane; 1: Baylis-Hillman reaction;

DOI:10.1055/s-2004-831179

Reference yield:

3-(2,4-dichloro-phenyl)-5-formyl-isoxazole-4-carboxylic acid methyl ester (682352-77-8) → 5-(1-acetoxy-2-tert-butoxycarbonyl-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester (811446-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / DABCO / tetrahydrofuran / 0.08 h / 20 °C

2: 90 percent / pyridine / CH₂Cl₂ / 0.08 h / 0 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; dichloromethane; 1: Baylis-Hillman reaction;

DOI:10.1055/s-2004-831179

upstream raw materials:

acetyl chloride

5-(2-tert-butoxycarbonyl-1-hydroxy-allyl)-3-(2,4-dichloro-phenyl)-isoxazole-4-carboxylic acid methyl ester

tert-Butyl acrylate

3-(2,4-dichloro-phenyl)-5-formyl-isoxazole-4-carboxylic acid methyl ester

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