2-[(4-chlorobenzyl)-(6-methyl-2-phenyl-5-phenylethynylpyrimidin-4-yl)-amino]-4-methylpentanoic acid 4-methoxybenzylamide

Base Information

Chemical Name:2-[(4-chlorobenzyl)-(6-methyl-2-phenyl-5-phenylethynylpyrimidin-4-yl)-amino]-4-methylpentanoic acid 4-methoxybenzylamide
CAS No.:1461736-27-5
Molecular Formula:C₄₀H₃₉ClN₄O₂
Molecular Weight:643.228
Hs Code.:

Synonyms:2-[(4-chlorobenzyl)-(6-methyl-2-phenyl-5-phenylethynylpyrimidin-4-yl)-amino]-4-methylpentanoic acid 4-methoxybenzylamide

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Chemical Property of 2-[(4-chlorobenzyl)-(6-methyl-2-phenyl-5-phenylethynylpyrimidin-4-yl)-amino]-4-methylpentanoic acid 4-methoxybenzylamide

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Technology Process of 2-[(4-chlorobenzyl)-(6-methyl-2-phenyl-5-phenylethynylpyrimidin-4-yl)-amino]-4-methylpentanoic acid 4-methoxybenzylamide

There total 4 articles about 2-[(4-chlorobenzyl)-(6-methyl-2-phenyl-5-phenylethynylpyrimidin-4-yl)-amino]-4-methylpentanoic acid 4-methoxybenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1461736-12-8
2-((4-chlorobenzyl)-(5-iodo-6-methyl-2-phenylpyrimidin-4-yl)amino)-N-(4-methoxybenzyl)-4-methylpentanamide

: 536-74-3
phenylacetylene

: 1461736-27-5
2-[(4-chlorobenzyl)-(6-methyl-2-phenyl-5-phenylethynylpyrimidin-4-yl)-amino]-4-methylpentanoic acid 4-methoxybenzylamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃;
DOI:10.1039/c3ob41477a

Reference yield:

: 1197-58-6
1-(isocyanomethyl)-4-methoxybenzene

: 1461736-27-5
2-[(4-chlorobenzyl)-(6-methyl-2-phenyl-5-phenylethynylpyrimidin-4-yl)-amino]-4-methylpentanoic acid 4-methoxybenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 72 h / 60 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1039/c3ob41477a

Reference yield:

: 104-86-9
4-chlorobenzylamine

: 1461736-27-5
2-[(4-chlorobenzyl)-(6-methyl-2-phenyl-5-phenylethynylpyrimidin-4-yl)-amino]-4-methylpentanoic acid 4-methoxybenzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 72 h / 60 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / acetonitrile / 70 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In methanol; acetonitrile; 2: |Sonogashira Cross-Coupling;
DOI:10.1039/c3ob41477a